PCNA-Proliferation Marker Antibody, ALEXA FLUOR 488

Catalog number:	bs-2006R-A488 Buy Now
Price:	332 €
Supplier:	Bioss Primary Conjugated Antibodies.
Product name:	PCNA-Proliferation Marker Antibody, ALEXA FLUOR 488
Quantity:	100ul
Related search:	antibody dna fluor antibodies gene replication damage photo

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Long name:	ALEXA FLUOR 488 Conjugated, PCNA-Proliferation Marker Antibody
Also known as:	Anti-PCNA-proliferation Marker PAb ALEXA FLUOR 488
Category:	Conjugated Primary Antibodies
Conjugated with:	488, ALEXA FLUOR®
Host Organism:	Rabbit (Oryctolagus cuniculus)
Target Antigen:	PCNA-proliferation Marker
Specificity:	This is a highly specific antibody against PCNA-proliferation Marker
Modification:	Unmodified
Modification Site:	None
Clonality:	Polyclonal
Clone:	Polyclonal antibody
Concentration:	1ug per 1ul
Immunogen range:	209-241/261
Subcellular location:	Helical, Nucleus
Source:	This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human PCNA
Gene ID Number:	5111
Swiss Prot:	P12004
Tested applications:	IF(IHC-P)
Recommended dilutions:	IF(IHC-P)(1:50-200)
Crossreactivity:	Mouse, Rat, Human
Cross-reactive species details:	not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the antigen:	APEX2 activities, Acts as a loading platform to recruit DDR proteins that allow completion of DNA replication after DNA damage and promote postreplication repair: Monoubiquitinated PCNA leads to recruitment of translesion (TLS) polymerases, Has to be loaded onto DNA in order to be able to stimulate APEX2, Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'-phosphodiesterase, Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA repair and DNA damage tolerance pathways, but not apurinic-apyrimidinic (AP) endonuclease, while 'Lys-63'-linked polyubiquitination of PCNA is involved in error-free pathway and employs recombination mechanisms to synthesize across the lesion, Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand
Purification:	Purified by Protein A
Storage conditions:	50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA
Excitation emission:	499nm/519nm
Properties:	ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 488 has the same range to that of fluorescein isothiocyanate (FITC), Also Alexa Fluor 488 is pH stable, As a result of this photo stability, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, It is distinguished in the FL1 of a FACS-Calibur or FACScan, has a very high photo stability, it has turned into an antibody for fluorescent microscopy and FACS FLOW cytometry, yet the PCNA-Proliferation Marker Antibody, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate
Conjugation:	Alexa Fluor
Gene target:	PCNA-Proliferation
Short name:	PCNA-Proliferation Marker Antibody
Technique:	antibodies against human proteins, antibodies for, Antibody
Label:	ALEXA FLUOR 488
Alternative name:	ALEXA FLUOR 488, PCNA-expantion detection labelled (Antibody to)
Alternative technique:	antibodies
Identity:	8729
Gene:	PCNA | More about : PCNA
Long gene name:	proliferating cell nuclear antigen
Locus:	20p12, 3
Discovery year:	1990-01-15
GenBank acession:	J04718
Entrez gene record:	5111
Pubmed identfication:	2565339
Havana BLAST/BLAT:	OTTHUMG00000031798

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