| Long name: |
DNAJC3 Primary Polyclonal Antibody |
| Also known as: |
DNAJC3 PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
DNAJC3 |
| Specificity: |
This is a highly specific antibody against DNAJC3 |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
360-410/504 |
| Subcellular location: |
Cytoplasm |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human p58ipk/DNAJC3 |
| Gene ID number: |
5611 |
| Swiss Prot: |
Q13217 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
DNAJC3 is widely expressed and can be found at high levels in the testis and pancreas (expression in cell lines is variable), It also functions as a Co-chaperone of HSPA8/HSC70 and is involved in the unfolded protein response (UPR) during ER stress, It has been reported that this protein stimulates the ATPase activity of HSPA8/HSC70, DNAJC3 is also involved in ativiral defense - it is activated in response to infection by influenza virus through the dissociation of DNAJB1, DNAJC3 may act as an inhibitor of both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2/PKR to catalyze phosphorylation of the EIF2A |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
DnaJ homolog subfamily C member 3, HP58, Interferon induced, P58, P58IPK, PRKRI, Protein Kinase Inhibitor P58, Protein kinase inhibitor of 58 kDa, Protein kinase inhibitor p58, double stranded RNA activated protein kinase inhibitor, p58 ipk , DNAJC3 |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
DNAJC3 |
| Short name: |
DNAJC3 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
member 3 (Antibody to), subfamily C, DnaJ (Hsp40) homolog |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
BT, DNAJC3 and IDBG-43059 and ENSG00000102580 and 5611, Dnajc3 and IDBG-186994 and ENSMUSG00000022136 and 100037258, ERdj6 and HP58 and P58 and P58IPK and PRKRI, Plasma membranes, member 3, misfolded protein binding, subfamily C, this GO :0004860 and protein kinase inhibitor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005737 and cytoplasm and cellular component this GO :0005788 and endoplasmic reticulum lumen and cellular component this GO :0005790 and smooth endoplasmic reticulum and cellular component this GO :0006469 and negative regulation of protein kinase activity and biological process this GO :0006987 and activation of signaling protein activity involved in unfolded protein response and biological process this GO :0016020 and membrane and cellular component this GO :0030968 and endoplasmic reticulum unfolded protein response and biological process this GO :0031205 and endoplasmic reticulum Sec complex and cellular component this GO :0044267 and cellular protein metabolic process and biological process this GO :0051087 and chaperone binding and molecular function this GO :0051603 and proteolysis involved in cellular protein catabolic process and biological process this GO :0051607 and defense response to virus and biological process this GO :0051787 and misfolded protein binding and molecular function this GO :0070062 and extracellular vesicular exosome and cellular component, this GO :0004860 : protein kinase inhibitor activity, this GO :0004860 : protein kinase inhibitor activity and also this GO :0005515 : protein binding and also this GO :0051087 : chaperone binding and also this GO :0051787 : misfolded protein binding, this GO :0005515 : protein binding, this GO :0051087 : chaperone binding, this GO :0051787 : misfolded protein binding, 68903 and IDBG-632869 and ENSBTAG00000012065 and 286770, DnaJ (Hsp40) homolog |
| Identity: |
9439 |
| Gene: |
DNAJC3 |
More about : DNAJC3 |
| Long gene name: |
DnaJ heat shock protein family (Hsp40) member C3 |
| Synonyms gene: |
PRKRI |
| Synonyms gene name: |
DnaJ (Hsp40) homolog, member 3 , subfamily C |
| Synonyms: |
P58 P58IPK HP58 ERdj6 |
| Synonyms name: |
double-stranded RNA-activated protein kinase inhibitor protein kinase inhibitor of 58 kDa endoplasmic reticulum DNA J domain-containing protein 6 , interferon-induced |
| Locus: |
13q32, 1 |
| Discovery year: |
1995-09-20 |
| GenBank acession: |
U28424 |
| Entrez gene record: |
5611 |
| Pubmed identfication: |
7511204 8824806 |
| Classification: |
DNAJ (HSP40) heat shock proteins Tetratricopeptide repeat domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000017227 |