| Long name: |
FITC Conjugated, DNAJC3 Polyclonal Antibody |
| Category: |
Conjugated Primary Antibodies |
| Conjugation: |
Anti-FITC Antibody |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
DNAJC3 |
| Specificity: |
This is a highly specific antibody against DNAJC3 |
| Modification: |
Unmodified |
| Modification site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen_range: |
360-410/504 |
| Subcellular location: |
Cytoplasm |
| Source: |
KLH conjugated synthetic peptide derived from human p58ipk/DNAJC3 |
| Gene ID number: |
5611 |
| Swiss Prot: |
Q13217 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Crossreactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background: |
DNAJC3 is widely expressed and can be found at high levels in the testis and pancreas (expression in cell lines is variable), It also functions as a Co-chaperone of HSPA8/HSC70 and is involved in the unfolded protein response (UPR) during ER stress, It has been reported that this protein stimulates the ATPase activity of HSPA8/HSC70, DNAJC3 is also involved in ativiral defense - it is activated in response to infection by influenza virus through the dissociation of DNAJB1, DNAJC3 may act as an inhibitor of both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2/PKR to catalyze phosphorylation of the EIF2A |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Excitation Emission: |
494nm/518nm |
| Synonyms: |
P58 P58IPK HP58 ERdj6 |
| Properties: |
Bioss Primary Conjugated Antibodies FITC is highly sensitive to pH extremes, FITC has a green emission that's usually collected at 530 nanometers, FITC has a high quantum yield (efficiency of energy transfer from absorption to emission fluorescence) and approximately half of the absorbed photons are emitted as fluorescent light, For fluorescent microscopy applications, This Bioss Primary Conjugated Antibodies Fluorescein isothiocyanate (FITC) antibody is currently after some BD antibodies the most commonly used fluorescent dye for FACS, When excited at 488 nanometers, its photo bleaching effects are not observed due to a very brief interaction at the laser intercept, the 1 FITC is seldom used as it photo bleaches rather quickly though in flow cytometry applications, the FL1 detector of a FACSCalibur or FACScan, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
DNAJC3 Conjugated |
| Short name: |
FITC Conjugated, DNAJC3 Antibody |
| Technique: |
Fluorescein, antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label: |
FITC |
| Alternative name: |
fluorecein coupled, member 3 (Antibody to), subfamily C, DnaJ (Hsp40) homolog |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
BT, DNAJC3 and IDBG-43059 and ENSG00000102580 and 5611, Dnajc3 and IDBG-186994 and ENSMUSG00000022136 and 100037258, ERdj6 and HP58 and P58 and P58IPK and PRKRI, Plasma membranes, member 3, misfolded protein binding, subfamily C, this GO :0004860 and protein kinase inhibitor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005737 and cytoplasm and cellular component this GO :0005788 and endoplasmic reticulum lumen and cellular component this GO :0005790 and smooth endoplasmic reticulum and cellular component this GO :0006469 and negative regulation of protein kinase activity and biological process this GO :0006987 and activation of signaling protein activity involved in unfolded protein response and biological process this GO :0016020 and membrane and cellular component this GO :0030968 and endoplasmic reticulum unfolded protein response and biological process this GO :0031205 and endoplasmic reticulum Sec complex and cellular component this GO :0044267 and cellular protein metabolic process and biological process this GO :0051087 and chaperone binding and molecular function this GO :0051603 and proteolysis involved in cellular protein catabolic process and biological process this GO :0051607 and defense response to virus and biological process this GO :0051787 and misfolded protein binding and molecular function this GO :0070062 and extracellular vesicular exosome and cellular component, this GO :0004860 : protein kinase inhibitor activity, this GO :0004860 : protein kinase inhibitor activity and also this GO :0005515 : protein binding and also this GO :0051087 : chaperone binding and also this GO :0051787 : misfolded protein binding, this GO :0005515 : protein binding, this GO :0051087 : chaperone binding, this GO :0051787 : misfolded protein binding, 68903 and IDBG-632869 and ENSBTAG00000012065 and 286770, DnaJ (Hsp40) homolog |
| Identity: |
9439 |
| Gene: |
DNAJC3 |
More about : DNAJC3 |
| Long gene name: |
DnaJ heat shock protein family (Hsp40) member C3 |
| Synonyms gene: |
PRKRI |
| Synonyms gene name: |
DnaJ (Hsp40) homolog, member 3 , subfamily C |
| Synonyms name: |
double-stranded RNA-activated protein kinase inhibitor protein kinase inhibitor of 58 kDa endoplasmic reticulum DNA J domain-containing protein 6 , interferon-induced |
| Locus: |
13q32, 1 |
| Discovery year: |
1995-09-20 |
| GenBank acession: |
U28424 |
| Entrez gene record: |
5611 |
| Pubmed identfication: |
7511204 8824806 |
| Classification: |
DNAJ (HSP40) heat shock proteins Tetratricopeptide repeat domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000017227 |