| Long name: |
ATF2 (Ser490/498) Primary Polyclonal Antibody |
| Also known as: |
ATF2 (Ser490/498) PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
ATF2 Ser490/498 |
| Specificity: |
This is a highly specific antibody against ATF2 Ser490/498 |
| Modification(s): |
Phosphorylation |
| Modification site(s): |
Ser490/498 |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
KLH conjugated synthetic phosphopeptide derived from human ATF2 around the phosphorylation site of Ser490/498 |
| Gene ID number: |
1386 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
ATF2 is a nuclear protein that binds DNA as a dimer and can form dimers with members of the ATF/CREB and Jun/Fos families, ATF2 is abundantly expressed in brain, Following dimerization ATF2 becomes a short lived protein that undergoes ubiquitination and proteolysis, It is a stronger activator as a heterodimer with cJun than as a homodimer, Many of these genes are important in cell growth and differentiation, Several isoforms of ATF2 arise by differential splicing, Stimulation of the transcriptional activity of ATF2 occurs following cellular stress induced by several genotoxic agents, The stable native full length ATF2 is transcriptionally inactive as a result of an inhibitory direct intramolecular interaction of its carboxy terminal DNA binding domain with the amino terminal transactivation domain, This activation requires phosphorylation of two threonine residues in ATF2 by both JNK/SAP kinase and p38 MAP kinase, and UV irradiation, and in stress and immune responses, inflammatory cytokines, seemingly in a protein phosphatase-dependent mechanism, ATF2 is a member of the ATF/CREB family of basic region leucine zipper DNA binding proteins that regulates transcription by binding to a consensus cAMP response element (CRE) in the promoter of various viral and cellular genes |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
ATF 2, ATF2 phospho S490 + S498, ATF2 protein, Atf-2, CRE BP1, CRE-BP, CREB 2, CREB 2, CREB2, CREBP1, Cyclic AMP dependent transcription factor ATF 2, Cyclic AMP-responsive, HB 16, cAMP Response Element Binding Protein 2, cAMP response element binding protein CRE BP1, cAMP-dependent transcription factor ATF-2, cAMP-responsive element-binding protein 2, p-ATF2 phospho S490, p-ATF2 phospho S490 + S498, ATF2 phospho S490, Activating Transcription Factor 2 |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
ATF2 (Ser490/498) |
| Short name: |
ATF2 (Ser490/498) Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
ATF2 (Ser490/498) (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
4232 |
| Gene: |
GDNF |
More about : GDNF |
| Long gene name: |
glial cell derived neurotrophic factor |
| Synonyms: |
ATF1 ATF2 HFB1-GDNF |
| Synonyms name: |
astrocyte-derived trophic factor glial cell line derived neurotrophic factor glial derived neurotrophic factor |
| Locus: |
5p13, 2 |
| Discovery year: |
1995-05-04 |
| Entrez gene record: |
2668 |
| Pubmed identfication: |
8493557 |
| RefSeq identity: |
NM_000514 |
| Classification: |
Endogenous ligands |
| Havana BLAST/BLAT: |
OTTHUMG00000090809 |