| Gene info: |
ATF expression has also been linked to the depression in humans, ATF-2 has been implicated in the transcriptional regulation of a number of genes including cytokines, ATF2 is particularly abundant in the brain and the ATF2 family of transcription factors is considered important substrates of signals upstream of the activation of genes associated with neuronal growth and differentiation, In addition, Serine 490 and serine 498 are novel phosphorylation sites on ATF that have recently been identified, Stress induced ATF-dependent transcription is dependent on phosphorylation of ATF, Various forms of cellular stress, cell cycle control and apoptosis, including inflammatory cytokines and UV irradiation, stimulate the transcriptional activity of ATF-2, The activating transcription factor ATF-2 (also called CRE-BP1) binds to both AP-1 and CRE DNA response elements and is a member of the ATF/CREB family of leucine zipper proteins |
| Gene names: |
Activating transcription factor 2, CRE-BP1, CREB-2, CREB2, CREBP1, TREB7, cAMP-dependent transcription factor ATF-2, HB16 |
| Antibodie's label: |
unlabelled serum |
| Purity: |
Affinity Purified |
| Ab raised in: |
Rabbit |
| Type: |
Polyclonal |
| Spicific to: |
ATF2 antibody is specific for ~74k ATF2 phosphorylated at Ser490/498 |
| Antigen: |
ATF-2 (Ser 490/498) polyclonal antibody was made against a synthetic phosphopeptide corresponding to amino acids residues surrounding the human phospho Ser490/498 of ATF2 |
| Immuno application: |
immuno-histo-chemistry, Western Blot |
| Antibody advice: |
Applications include Dot Blots (DB), IHC and WB, Immunohistochemistry (IHC) and Western Blots (WB), When internally tested under ideal conditions the working dilutions were 1:1000 for DB, The antibody also recognizes the phosphorylated 54k splice form of ATF2 |
| Suspention, pH, azide: |
100 ug per mL BSA and 50% glycerol, 150 mM NaCl, 100 uL in 10 mM HEPES (pH 7, 5) |
| Keep at: |
Stable for one year, but shorter term storage at &ndash, 20 grades C is also acceptable as aliquots may be taken without freeze/thawing due to the presence of 50% glycerol, 80 grades C is recommended, For long term storage &ndash |
| Works with: |
Human |
| Omim nr: |
215274241 |
| Ncbi nr: |
P15336 |
| KDa: |
74 |
| Vial with antibody: |
in solution |
| NCBI GENE nr: |
1386 |
| GENE symbol: |
ATF2 |
| Antigene name: |
activating transcription factor 2 |
| Source: |
Homo sapiens |
| Protein nr: |
P15336 |
| Description: |
Freeze thaw will destroy a percentage in every cycle and should be avoided, C in a fridge short term in a concentrated dilution, This antibody needs to be stored at + 4° |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by proscience they should be stored frozen at - 24° |
| Gene target: |
ATF2 (phospho Ser 490 / 498) |
| Short name: |
anti-ATF2 (phospho Ser 490 / 498) Antibody |
| Technique: |
antibodies against human proteins, antibodies for, antibody to, Antibody |
| Alternative name: |
antibody to-ATF2 (phosphorilated L-serine 490 / 498) (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
4232 |
| Gene: |
GDNF |
More about : GDNF |
| Long gene name: |
glial cell derived neurotrophic factor |
| Synonyms: |
ATF1 ATF2 HFB1-GDNF |
| Synonyms name: |
astrocyte-derived trophic factor glial cell line derived neurotrophic factor glial derived neurotrophic factor |
| Locus: |
5p13, 2 |
| Discovery year: |
1995-05-04 |
| Entrez gene record: |
2668 |
| Pubmed identfication: |
8493557 |
| RefSeq identity: |
NM_000514 |
| Classification: |
Endogenous ligands |
| Havana BLAST/BLAT: |
OTTHUMG00000090809 |