| Long name: |
FITC Conjugated, HIC2 Polyclonal Antibody |
| Category: |
Conjugated Primary Antibodies |
| Conjugation: |
Anti-FITC Antibody |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
HIC2 |
| Specificity: |
This is a highly specific antibody against HIC2 |
| Modification: |
Unmodified |
| Modification site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
KLH conjugated synthetic peptide derived from human HIC2 |
| Gene ID number: |
23119 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Crossreactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background: |
HIC-2 (hypermethylated in cancer 2) possesses zinc finger motifs that are thought to be important for DNA-binding and also has a BTB/POZ domain at the N-terminus, HIC-2 contains a short amino acid sequence that is thought to interact with CtBP, HIC-2 is also known as Hic-3, HIC-2 is highly expressed in cerebellum and is localized to the nucleus in cells, HIC1-related gene on chromosome 22 or Zinc finger and BTB domain-containing protein 30, The gene sequence associated with HIC-2 is thought to be a target for miRNAs (microRNAs) which are expressed in many cancers, The majority of zinc-finger proteins contain a KrÃ, a transcriptional repressor, and is a 615 amino acid protein that is expressed as two isoforms produced by alternative splicing, as well as for the binding of transcription factors, most of which encompass some form of transcriptional activation or repression, suggesting that HIC-2 could possess tumor suppressor capabilities, thereby recruiting histone modifying proteins, which is thought to be important for protein-protein binding, which is thought to interact with KAP1, ¼, Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, ppel-type DNA binding domain and a KRAB domain |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Excitation Emission: |
494nm/518nm |
| Synonyms: |
KIAA1020 HRG22 ZBTB30 ZNF907 |
| Properties: |
Bioss Primary Conjugated Antibodies FITC is highly sensitive to pH extremes, FITC has a green emission that's usually collected at 530 nanometers, FITC has a high quantum yield (efficiency of energy transfer from absorption to emission fluorescence) and approximately half of the absorbed photons are emitted as fluorescent light, For fluorescent microscopy applications, This Bioss Primary Conjugated Antibodies Fluorescein isothiocyanate (FITC) antibody is currently after some BD antibodies the most commonly used fluorescent dye for FACS, When excited at 488 nanometers, its photo bleaching effects are not observed due to a very brief interaction at the laser intercept, the 1 FITC is seldom used as it photo bleaches rather quickly though in flow cytometry applications, the FL1 detector of a FACSCalibur or FACScan, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
HIC2 Conjugated |
| Short name: |
FITC Conjugated, HIC2 Antibody |
| Technique: |
Fluorescein, antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label: |
FITC |
| Alternative name: |
fluorecein coupled, HIC2 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
18595 |
| Gene: |
HIC2 |
More about : HIC2 |
| Long gene name: |
HIC ZBTB transcriptional repressor 2 |
| Synonyms gene name: |
hypermethylated in cancer 2 |
| Locus: |
22q11, 21 |
| Discovery year: |
2002-04-29 |
| GenBank acession: |
AB028943 |
| Entrez gene record: |
23119 |
| Pubmed identfication: |
11554746 |
| Classification: |
BTB domain containing Zinc fingers C2H2-type |
| Havana BLAST/BLAT: |
OTTHUMG00000150781 |