| Long name: |
HIC2 Primary Polyclonal Antibody |
| Also known as: |
HIC2 PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
HIC2 |
| Specificity: |
This is a highly specific antibody against HIC2 |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human HIC2 |
| Gene ID number: |
23119 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
HIC-2 (hypermethylated in cancer 2) possesses zinc finger motifs that are thought to be important for DNA-binding and also has a BTB/POZ domain at the N-terminus, HIC-2 contains a short amino acid sequence that is thought to interact with CtBP, HIC-2 is also known as Hic-3, HIC-2 is highly expressed in cerebellum and is localized to the nucleus in cells, HIC1-related gene on chromosome 22 or Zinc finger and BTB domain-containing protein 30, The gene sequence associated with HIC-2 is thought to be a target for miRNAs (microRNAs) which are expressed in many cancers, The majority of zinc-finger proteins contain a KrÃ, a transcriptional repressor, and is a 615 amino acid protein that is expressed as two isoforms produced by alternative splicing, as well as for the binding of transcription factors, most of which encompass some form of transcriptional activation or repression, suggesting that HIC-2 could possess tumor suppressor capabilities, thereby recruiting histone modifying proteins, which is thought to be important for protein-protein binding, which is thought to interact with KAP1, ¼, Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, ppel-type DNA binding domain and a KRAB domain |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
HIC2, HIC2_HUMAN, HRG22, Hic3, Hypermethylated in cancer 2 protein, KIAA1020, ZBTB30, ZNF907, Zinc finger and BTB domain-containing protein 30, HIC1 related gene on chromosome 22 |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
HIC2 |
| Short name: |
HIC2 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
HIC2 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
18595 |
| Gene: |
HIC2 |
More about : HIC2 |
| Long gene name: |
HIC ZBTB transcriptional repressor 2 |
| Synonyms gene name: |
hypermethylated in cancer 2 |
| Synonyms: |
KIAA1020 HRG22 ZBTB30 ZNF907 |
| Locus: |
22q11, 21 |
| Discovery year: |
2002-04-29 |
| GenBank acession: |
AB028943 |
| Entrez gene record: |
23119 |
| Pubmed identfication: |
11554746 |
| Classification: |
BTB domain containing Zinc fingers C2H2-type |
| Havana BLAST/BLAT: |
OTTHUMG00000150781 |