| Long name: |
ALEXA FLUOR 647 Conjugated, Heparanase Polyclonal Antibody |
| Also known as: |
Anti-Heparanase PAb ALEXA FLUOR 647 |
| Category: |
Conjugated Primary Antibodies |
| Conjugated with: |
647, ALEXA FLUOR® |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
Heparanase |
| Specificity: |
This is a highly specific antibody against Heparanase |
| Modification: |
Unmodified |
| Modification Site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
140-190/543 |
| Subcellular location: |
Secreted, Nucleus |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Heparanase 50 kDa subunit |
| Gene ID Number: |
10855 |
| Swiss Prot: |
Q9Y251 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Cross-reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen: |
Acts as procoagulant by increasing the generation of activation factor X in the presence of tissue factor and activation factor VII, Can also cleave the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying a 2-O-sulfo group, Enhances angiogenesis through up-regulation of SRC-mediated activation of VEGF, Enhances shedding of syndecans, Facilitates cell migration associated with metastasis, Heparin increases this AKT1/PKB activation, Implicated in hair follicle inner root sheath differentiation and hair homeostasis, Increases cell adhesion to the extacellular matrix (ECM), Induces AKT1/PKB phosphorylation via lipid rafts increasing cell mobility and invasion, It is essentially inactive at neutral pH but becomes active under acidic conditions such as during tumor invasion and in inflammatory processes, Participates in extracellular matrix (ECM) degradation and remodeling, Regulates osteogenesis, Selectively cleaves the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying either a 3-O-sulfo or a 6-O-sulfo group, and increases endothelial invasion and angiogenesis in myelomas, but not linkages between a glucuronic acid unit and a 2-O-sulfated iduronic acid moiety, independent of its enzymatic activity, wound healing and inflammation, Endoglycosidase that cleaves heparan sulfate proteoglycans (HSPGs) into heparan sulfate side chains and core proteoglycans |
| Purification: |
Purified by Protein A |
| Storage conditions: |
50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission: |
650nm/665nm |
| Synonyms: |
HPA2 HPR2 HPSE2 |
| Properties: |
ALEXA FLUOR made this Alexa Fluor 633 conjugate that can be used in multi-color flow cytometry with instruments equipped with a second red laser or red diode, ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 633 is a practical alternative to APC as well as Cy5, Bioss Primary Conjugated Antibodies, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, It is detected in the FL4 detector of the core's upgraded 2-laser FACScans, Like other Alexa Fluor dyes, exhibits uncommon photo stability, making it an ideal choice for fluorescent microscopy, the Heparanase Antibody, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
ALEXA FLUOR 647, Alexa Fluor |
| Gene target: |
Heparanase |
| Short name: |
Heparanase Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Label: |
ALEXA FLUOR 647 |
| Alternative name: |
ALEXA FLUOR 647, Heparanase (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
12521 |
| Gene: |
UFS |
More about : UFS |
| Long gene name: |
heparanase 2 (inactive) |
| Synonyms gene name: |
urofacial syndrome heparanase 2 |
| Locus: |
10q24, 2 |
| Discovery year: |
2002-09-02 |
| GenBank acession: |
AF282885 |
| Entrez gene record: |
60495 |
| Pubmed identfication: |
11027606 20560210 9199567 20576607 |
| RefSeq identity: |
NM_021828 |
| Havana BLAST/BLAT: |
OTTHUMG00000018880 |