| Long name: |
FITC Conjugated, ATF4/CREB-2 Polyclonal Antibody |
| Category: |
Conjugated Primary Antibodies |
| Conjugation: |
Anti-FITC Antibody |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
ATF4/CREB-2 |
| Specificity: |
This is a highly specific antibody against ATF4/CREB-2 |
| Modification: |
Unmodified |
| Modification site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen_range: |
240-290/351 |
| Subcellular location: |
Cell membrane, Nucleus, Cytoplasm |
| Source: |
KLH conjugated synthetic peptide derived from human ATF4 |
| Gene ID number: |
468 |
| Swiss Prot: |
P18848 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Crossreactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background: |
Activates transcription of SIRT4, Binds in a circadian time-dependent manner to the cAMP response elements (CRE) in the SLC6A4 and PER2 promoters and periodically activates the transcription of these genes, Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), Cooperates with FOXO1 in osteoblasts to regulate glucose homeostasis through suppression of beta-cell production and decrease in insulin production (By similarity), In concert with DDIT3/CHOP, It binds to a Tax-responsive enhancer element in the long terminal repeat of HTLV-I, Regulates the circadian expression of the core clock component PER2 and the serotonin transporter SLC6A4, Regulates the induction of DDIT3/CHOP and asparagine synthetase (ASNS) in response to ER stress, a sequence present in many viral and cellular promoters, activates the transcription of TRIB3 and promotes ER stress-induced neuronal apoptosis by regulating the transcriptional induction of BBC3/PUMA, Transcriptional activator |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Excitation Emission: |
494nm/518nm |
| Synonyms: |
TAXREB67 CREB-2 |
| Properties: |
Bioss Primary Conjugated Antibodies FITC is highly sensitive to pH extremes, FITC has a green emission that's usually collected at 530 nanometers, FITC has a high quantum yield (efficiency of energy transfer from absorption to emission fluorescence) and approximately half of the absorbed photons are emitted as fluorescent light, For fluorescent microscopy applications, This Bioss Primary Conjugated Antibodies Fluorescein isothiocyanate (FITC) antibody is currently after some BD antibodies the most commonly used fluorescent dye for FACS, When excited at 488 nanometers, its photo bleaching effects are not observed due to a very brief interaction at the laser intercept, the 1 FITC is seldom used as it photo bleaches rather quickly though in flow cytometry applications, the FL1 detector of a FACSCalibur or FACScan, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
ATF4/CREB-2 Conjugated |
| Short name: |
FITC Conjugated, ATF4/CREB-2 Antibody |
| Technique: |
Fluorescein, antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label: |
FITC |
| Alternative name: |
fluorecein coupled, ATF4/CREB-2 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
786 |
| Gene: |
ATF4 |
More about : ATF4 |
| Long gene name: |
activating transcription factor 4 |
| Synonyms gene: |
TXREB |
| Synonyms gene name: |
activating transcription factor 4 (tax-responsive enhancer element B67) |
| Synonyms name: |
tax-responsive enhancer element B67 |
| Locus: |
22q13, 1 |
| Discovery year: |
1992-06-09 |
| GenBank acession: |
D90209 |
| Entrez gene record: |
468 |
| Pubmed identfication: |
1847461 1534408 |
| RefSeq identity: |
NM_001675 |
| Classification: |
Basic leucine zipper proteins |
| Havana BLAST/BLAT: |
OTTHUMG00000151099 |