| Long name: |
ATF4/CREB-2 Primary Polyclonal Antibody |
| Also known as: |
ATF4/CREB-2 PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
ATF4/CREB-2 |
| Specificity: |
This is a highly specific antibody against ATF4/CREB-2 |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
240-290/351 |
| Subcellular location: |
Cell membrane, Nucleus, Cytoplasm |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human ATF4 |
| Gene ID number: |
468 |
| Swiss Prot: |
P18848 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Activates transcription of SIRT4, Binds in a circadian time-dependent manner to the cAMP response elements (CRE) in the SLC6A4 and PER2 promoters and periodically activates the transcription of these genes, Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), Cooperates with FOXO1 in osteoblasts to regulate glucose homeostasis through suppression of beta-cell production and decrease in insulin production (By similarity), In concert with DDIT3/CHOP, It binds to a Tax-responsive enhancer element in the long terminal repeat of HTLV-I, Regulates the circadian expression of the core clock component PER2 and the serotonin transporter SLC6A4, Regulates the induction of DDIT3/CHOP and asparagine synthetase (ASNS) in response to ER stress, a sequence present in many viral and cellular promoters, activates the transcription of TRIB3 and promotes ER stress-induced neuronal apoptosis by regulating the transcriptional induction of BBC3/PUMA, Transcriptional activator |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
ATF4, Activating transcription factor 4, CREB-2, Cyclic AMP-dependent transcription factor ATF-4, Cyclic AMP-responsive element-binding protein 2, DNA-binding protein TAXREB67, TAXREB67, TXREB, Tax-responsive enhancer element-binding protein 67, cAMP-dependent transcription factor ATF-4, cAMP-responsive element-binding protein 2, CREB2 |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
ATF4/CREB-2 |
| Short name: |
ATF4/CREB-2 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
ATF4/CREB-2 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
786 |
| Gene: |
ATF4 |
More about : ATF4 |
| Long gene name: |
activating transcription factor 4 |
| Synonyms gene: |
TXREB |
| Synonyms gene name: |
activating transcription factor 4 (tax-responsive enhancer element B67) |
| Synonyms: |
TAXREB67 CREB-2 |
| Synonyms name: |
tax-responsive enhancer element B67 |
| Locus: |
22q13, 1 |
| Discovery year: |
1992-06-09 |
| GenBank acession: |
D90209 |
| Entrez gene record: |
468 |
| Pubmed identfication: |
1847461 1534408 |
| RefSeq identity: |
NM_001675 |
| Classification: |
Basic leucine zipper proteins |
| Havana BLAST/BLAT: |
OTTHUMG00000151099 |