ErbB-3/HER3 Antibody, Biotin Conjugated

Catalog number:	bs-1454R-Biotin Buy Now
Price:	350 €
Supplier:	Bioss Primary Conjugated Antibodies
Product name:	ErbB-3/HER3 Antibody, Biotin Conjugated
Quantity:	0.1ml
Related search:	gene erbb antibodies receptor synonyms tyrosine factor

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Long name:	Biotin Conjugated, ErbB-3/HER3 Polyclonal Antibody
Category:	Conjugated Primary Antibodies
Conjugation:	Biotinylated
Host Organism:	Rabbit (Oryctolagus cuniculus)
Target Antigen:	ErbB-3/HER3
Specificity:	This is a highly specific antibody against ErbB-3/HER3
Modification:	Unmodified
Modification site:	None
Clonality:	Polyclonal
Clone:	Polyclonal antibody
Concentration:	1ug per 1ul
Immunogen_range:	670-720/1342
Subcellular location:	Cytoplasm
Source:	KLH conjugated synthetic peptide derived from human ErbB-3
Gene ID number:	2065
Swiss Prot:	P21860
Tested applications:	IHC-P
Recommended dilutions:	IHC-P(1:100-500)
Crossreactivity:	Mouse, Rat, Human
Crossreactive species details:	not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Antigen background:	Additional splice variants have also been reported but they have not been thoroughly characterized, Alternate transcriptional splice variants encoding different isoforms have been characterized, Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers including prostate, ErbB3 is a membrane-bound protein which has a neuregulin binding domain but not an active kinase domain, Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation, However it does form heterodimers with other EGF receptor family members which do have kinase activity, It can therefore bind this ligand but cannot convey a signal into the cell via protein phosphorylation, One isoform lacks the intermembrane region and is secreted outside the cell, This form acts to modulate the activity of the membrane-bound form, bladder and breast tumors, The ErbB3 gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases
Purification method:	This antibody was purified via Protein A
Storage conditions:	50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA
Synonyms:	HER3
Properties:	Avidin and Streptavidin bind to the small biotin and are couple to HRP or AP for ELISA, Biotin conjugates can be detected by horseradish peroxidase, To break the streptavidin Biotin bond we suggest to use a 6 molar guanidine HCl solution with acidity of pH 1, alkaline phosphatase substrates or anti biotin conjugated antibodies, 6, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°
Gene target:	ErbB-3/HER3 Conjugated
Short name:	Conjugated, ErbB-3/HER3 Antibody
Technique:	antibodies against human proteins, antibodies for, antibody Conjugates, Antibody
Label:	Biotin
Alternative name:	biotinilated coupled, ErbB-3/HER3 (Antibody to)
Alternative technique:	antibodies
Identity:	3431
Gene:	ERBB3 | More about : ERBB3
Long gene name:	erb-b2 receptor tyrosine kinase 3
Synonyms gene:	LCCS2
Synonyms gene name:	lethal congenital contracture syndrome 2 v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3
Synonyms name:	human epidermal growth factor receptor 3
Locus:	12q13, 2
Discovery year:	1990-07-15
GenBank acession:	M34309
Entrez gene record:	2065
RefSeq identity:	NM_001982
Classification:	Erb-b2 receptor tyrosine kinases
Havana BLAST/BLAT:	OTTHUMG00000170140
Locus Specific Databases:	LRG_996

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