| Long name: |
Cy5, 5 Conjugated, TOM1L1 Polyclonal Antibody |
| Category: |
Conjugated Primary Antibodies |
| Conjugation: |
Cy5, 5, 5, Cy5 |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
TOM1L1 |
| Specificity: |
This is a highly specific antibody against TOM1L1 |
| Modification: |
Unmodified |
| Modification site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
KLH conjugated synthetic peptide derived from human TOM1L1 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Human |
| Crossreactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background: |
As an interactor and a substrate of Src tyrosine kinases (SFK), Containing a GAT domain and a VHS domain, GAT domain of Tom1L1 binds ubiquitin, GRB2, It is suggested that Tom1L-1 functions as an anti-oncogene by inhibiting the formation of squamous cell carcinomas in skin, PI 3-kinase p85?and various signaling proteins when phosphorylated, Tom1L-1 interacts with Fyn, Tom1L-1 may act as an adapter protein involved in signaling pathways and may promote Fyn activation, Tom1L1 is considered a novel mechanism involved in negative regulation of SFK mitogenic and transforming signals, Tom1L1 modulates SFK partitioning at the plasma membrane and downregulates Src kinases in an endosomal-dependent manner, possibly by disrupting intramolecular SH3-dependent interactions, suggesting participation in the sorting of ubiquitinated proteins into MVBs, Tom1L-1 is a 476 amino acid Golgi apparatus protein belonging to the TOM1 family and is a member of the multivesicular body (MVB) sorting machinery |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Excitation Emission: |
675nm/694nm |
| Synonyms: |
SRCASM |
| Properties: |
Cy5 antibodies are excited by the 650-nanometer wave of an argon laser and detected at a 670-nanometer captor, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24° |
| Conjugated: |
These antibodies are excite for emission at 678nm and detected at a 694 , nm wavelengths |
| Gene target: |
TOM1L1 Conjugated |
| Short name: |
Conjugated, TOM1L1 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label: |
5, Cy5 |
| Alternative name: |
cyanine 5, 5 coupled, TOM1L1 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
11983 |
| Gene: |
TOM1L1 |
More about : TOM1L1 |
| Long gene name: |
target of myb1 like 1 membrane trafficking protein |
| Synonyms gene name: |
target of myb1 (chicken) homolog-like 1 target of myb1 (chicken)-like 1 |
| Locus: |
17q23, 2 |
| Discovery year: |
1998-10-14 |
| GenBank acession: |
AJ010071 |
| Entrez gene record: |
10040 |
| Pubmed identfication: |
10329004 15611048 17977829 |
| RefSeq identity: |
NM_005486 |
| Havana BLAST/BLAT: |
OTTHUMG00000177816 |