| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
TOM1L1 |
| Specificity: |
This antibody reacts specifically with TOM1L1 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human TOM1L1 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
As an interactor and a substrate of Src tyrosine kinases (SFK), Containing a GAT domain and a VHS domain, GAT domain of Tom1L1 binds ubiquitin, GRB2, It is suggested that Tom1L-1 functions as an anti-oncogene by inhibiting the formation of squamous cell carcinomas in skin, PI 3-kinase p85?and various signaling proteins when phosphorylated, Tom1L-1 interacts with Fyn, Tom1L-1 may act as an adapter protein involved in signaling pathways and may promote Fyn activation, Tom1L1 is considered a novel mechanism involved in negative regulation of SFK mitogenic and transforming signals, Tom1L1 modulates SFK partitioning at the plasma membrane and downregulates Src kinases in an endosomal-dependent manner, possibly by disrupting intramolecular SH3-dependent interactions, suggesting participation in the sorting of ubiquitinated proteins into MVBs, Tom1L-1 is a 476 amino acid Golgi apparatus protein belonging to the TOM1 family and is a member of the multivesicular body (MVB) sorting machinery |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
SRCASM |
| Also known as: |
TOM1L1 Polyclonal Antibody |
| Other name: |
Anti-TOM1L1 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
TOM1L1 |
| Short name: |
Anti-TOM1L1 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-TOM1L1 (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
11983 |
| Gene: |
TOM1L1 |
More about : TOM1L1 |
| Long gene name: |
target of myb1 like 1 membrane trafficking protein |
| Synonyms gene name: |
target of myb1 (chicken) homolog-like 1 target of myb1 (chicken)-like 1 |
| Locus: |
17q23, 2 |
| Discovery year: |
1998-10-14 |
| GenBank acession: |
AJ010071 |
| Entrez gene record: |
10040 |
| Pubmed identfication: |
10329004 15611048 17977829 |
| RefSeq identity: |
NM_005486 |
| Havana BLAST/BLAT: |
OTTHUMG00000177816 |