| Long name: |
ALEXA FLUOR 647 Conjugated, TOM1L1 Polyclonal Antibody |
| Also known as: |
Anti-TOM1L1 PAb ALEXA FLUOR 647 |
| Category: |
Conjugated Primary Antibodies |
| Conjugated with: |
647, ALEXA FLUOR® |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
TOM1L1 |
| Specificity: |
This is a highly specific antibody against TOM1L1 |
| Modification: |
Unmodified |
| Modification Site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human TOM1L1 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Human |
| Cross-reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen: |
As an interactor and a substrate of Src tyrosine kinases (SFK), Containing a GAT domain and a VHS domain, GAT domain of Tom1L1 binds ubiquitin, GRB2, It is suggested that Tom1L-1 functions as an anti-oncogene by inhibiting the formation of squamous cell carcinomas in skin, PI 3-kinase p85?and various signaling proteins when phosphorylated, Tom1L-1 interacts with Fyn, Tom1L-1 may act as an adapter protein involved in signaling pathways and may promote Fyn activation, Tom1L1 is considered a novel mechanism involved in negative regulation of SFK mitogenic and transforming signals, Tom1L1 modulates SFK partitioning at the plasma membrane and downregulates Src kinases in an endosomal-dependent manner, possibly by disrupting intramolecular SH3-dependent interactions, suggesting participation in the sorting of ubiquitinated proteins into MVBs, Tom1L-1 is a 476 amino acid Golgi apparatus protein belonging to the TOM1 family and is a member of the multivesicular body (MVB) sorting machinery |
| Purification: |
Purified by Protein A |
| Storage conditions: |
50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission: |
650nm/665nm |
| Synonyms: |
SRCASM |
| Properties: |
ALEXA FLUOR made this Alexa Fluor 633 conjugate that can be used in multi-color flow cytometry with instruments equipped with a second red laser or red diode, ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 633 is a practical alternative to APC as well as Cy5, Bioss Primary Conjugated Antibodies, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, It is detected in the FL4 detector of the core's upgraded 2-laser FACScans, Like other Alexa Fluor dyes, exhibits uncommon photo stability, making it an ideal choice for fluorescent microscopy, the TOM1L1 Antibody, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
ALEXA FLUOR 647, Alexa Fluor |
| Gene target: |
TOM1L1 |
| Short name: |
TOM1L1 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Label: |
ALEXA FLUOR 647 |
| Alternative name: |
ALEXA FLUOR 647, TOM1L1 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
11983 |
| Gene: |
TOM1L1 |
More about : TOM1L1 |
| Long gene name: |
target of myb1 like 1 membrane trafficking protein |
| Synonyms gene name: |
target of myb1 (chicken) homolog-like 1 target of myb1 (chicken)-like 1 |
| Locus: |
17q23, 2 |
| Discovery year: |
1998-10-14 |
| GenBank acession: |
AJ010071 |
| Entrez gene record: |
10040 |
| Pubmed identfication: |
10329004 15611048 17977829 |
| RefSeq identity: |
NM_005486 |
| Havana BLAST/BLAT: |
OTTHUMG00000177816 |