| Long name: |
SLAP Primary Polyclonal Antibody |
| Also known as: |
SLAP PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
SLAP |
| Specificity: |
This is a highly specific antibody against SLAP |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human SLAP |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
3BP1 has been identified as a protein with a high affinity proline-rich binding site for the SH3 domain of c-Abl p120, A similar putative adapter protein, Deletion or mutation of SH3 domains generally activate the transforming potential of nonreceptor tyrosine kinases, In general, SH3 domains are often accompanied by SH2 domains of 100 amino acids, Slap contains a single SH2 and SH3 domain that exhibits homology with those from members of the Src kinase family, The N- and C-termini, The functions of SH3 domains are not as well defined, and in small adapter proteins, are unique, as in the nonreceptor protein-tyrosine kinases and phospholipase C-? within structural proteins, designated Slap, for Src-like adapter protein, frequently linking activated growth factors to putative signal transduction proteins, has been cloned, however, it exists in association with catalytic domains, such as Crk and GRB2, such as spectrin or Myosin, suggesting that SH3 mediates negative regulation of an intrinsic transforming activity, which bind to tyrosine-phosphorylated regions of target proteins, The Src homology 3 (SH3) region is a small protein domain of approximately 60 amino acids present in a large group of proteins |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
SLA, SLA 1, SLA1, SLAP, SLAP 1, SLAP-1, SLAP1, SLAP1_HUMAN, SRC-like-adapter, Src like adapter, Src like adapter protein 1, Src like adaptor, Src-like-adapter protein 1, hSLAP |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
SLAP |
| Short name: |
SLAP Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
SLAP (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
16643 |
| Gene: |
SLMAP |
More about : SLMAP |
| Long gene name: |
sarcolemma associated protein |
| Synonyms: |
SLAP KIAA1601 |
| Synonyms name: |
Sarcolemmal-associated protein |
| Locus: |
3p14, 3 |
| Discovery year: |
2001-12-03 |
| GenBank acession: |
AF100750 |
| Entrez gene record: |
7871 |
| Pubmed identfication: |
9405447 11042152 |
| RefSeq identity: |
NM_007159 |
| Classification: |
STRIPAK complex |
| Havana BLAST/BLAT: |
OTTHUMG00000133764 |