| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
SLAP |
| Specificity: |
This antibody reacts specifically with SLAP |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human SLAP |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
3BP1 has been identified as a protein with a high affinity proline-rich binding site for the SH3 domain of c-Abl p120, A similar putative adapter protein, Deletion or mutation of SH3 domains generally activate the transforming potential of nonreceptor tyrosine kinases, In general, SH3 domains are often accompanied by SH2 domains of 100 amino acids, Slap contains a single SH2 and SH3 domain that exhibits homology with those from members of the Src kinase family, The N- and C-termini, The functions of SH3 domains are not as well defined, and in small adapter proteins, are unique, as in the nonreceptor protein-tyrosine kinases and phospholipase C-? within structural proteins, designated Slap, for Src-like adapter protein, frequently linking activated growth factors to putative signal transduction proteins, has been cloned, however, it exists in association with catalytic domains, such as Crk and GRB2, such as spectrin or Myosin, suggesting that SH3 mediates negative regulation of an intrinsic transforming activity, which bind to tyrosine-phosphorylated regions of target proteins, The Src homology 3 (SH3) region is a small protein domain of approximately 60 amino acids present in a large group of proteins |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
SLAP KIAA1601 |
| Also known as: |
SLAP Polyclonal Antibody |
| Other name: |
Anti-SLAP Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
SLAP |
| Short name: |
Anti-SLAP (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-SLAP (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
16643 |
| Gene: |
SLMAP |
More about : SLMAP |
| Long gene name: |
sarcolemma associated protein |
| Synonyms name: |
Sarcolemmal-associated protein |
| Locus: |
3p14, 3 |
| Discovery year: |
2001-12-03 |
| GenBank acession: |
AF100750 |
| Entrez gene record: |
7871 |
| Pubmed identfication: |
9405447 11042152 |
| RefSeq identity: |
NM_007159 |
| Classification: |
STRIPAK complex |
| Havana BLAST/BLAT: |
OTTHUMG00000133764 |