| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
Bovine Fibrinogen |
| Specificity: |
This antibody reacts specifically with Bovine Fibrinogen |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
Fibrinogen from bovine plasma |
| Gene ID: |
522039 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Bovine |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
All chains are connected with each other by a number of disulfide bonds, All these facts make fibrinogen an important parameter in the diagnosis of cardiovascular diseases, An increase in blood fibrinogen concentration was shown to be a strong predictor of coronary heart disease (Sonel A, Fibrinogen activation is also involved in pathogenesis of inflammation, Fibrinogen clotting underlies pathogenesis of MI, Fibrinopeptides A (1 to 16 amino acids) and B (1 to 17 amino acids) are released by thrombin from the N terminal parts of alpha and beta chains, In this way fibrinogen is converted into fibrin, It is a large protein and it consists of two identical subunits that contain three polypeptide chains: alpha, The elevated level of fibrinogen in patient's blood is regarded as an independent risk factor for cardiovascular diseases, The normal fibrinogen concentration in plasma is about 3 mg/ml, and Rapold H, beta and gamma, et al, et al), respectively, since fibrin is the main substrate for thrombus formation, thromboembolism and thromboses of arteries and veins, tumor growth and many other diseases, which by means of polymerization forms a fibrin clot, Fibrinogen is the main protein of blood coagulation system, J |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Also known as: |
Bovine Fibrinogen Polyclonal Antibody |
| Other name: |
Anti-Bovine Fibrinogen Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
Fibrinogen |
| Short name: |
Anti- Fibrinogen (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Species: |
Bos Taurus genes are available form the Bovine Genome database, Bovine |
| Alternative name: |
ALEXA Fluor 594, antibody to-Bovine Fibrinogen (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
43653 |
| Gene: |
FSBP |
More about : FSBP |
| Long gene name: |
fibrinogen silencer binding protein |
| Locus: |
8q22, 1 |
| Discovery year: |
2012-01-10 |
| Entrez gene record: |
100861412 |
| Pubmed identfication: |
20531236 |
| RefSeq identity: |
NM_001256141 |
| Havana BLAST/BLAT: |
OTTHUMG00000178341 |