| Long name: |
Biotin Conjugated, NPC2/Niemann Pick C2 Polyclonal Antibody |
| Category: |
Conjugated Primary Antibodies |
| Conjugation: |
Biotinylated |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
NPC2/Niemann Pick C2 |
| Specificity: |
This is a highly specific antibody against NPC2/Niemann Pick C2 |
| Modification: |
Unmodified |
| Modification site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
KLH conjugated synthetic peptide derived from human Niemann Pick C2 |
| Tested applications: |
IHC-P, WB |
| Recommended dilutions: |
IHC-P(1:100-500), WB(1:100-1000) |
| Crossreactivity: |
Mouse, Rat, Human |
| Crossreactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background: |
Mutations in the NPC2 gene may cause Nieman-Pick type C2 disease and frontal lobe atrophy (1, NPC2 regulates the lipid composition of sperm membranes during maturation in the epididymis(1, Nieman-Pick type C2 is a fatal hereditary disease characterized by defective lysosome release of cholesterol (3), The disease is caused by HE1 deficiency, This differentiates NPC2 from NPC1, a lysosmal protein proven to be undetectable in fibroblasts from NPC2 patients (3), as NPC1 has HE1 protein present (3), 2, 2), 2), 3 (1, 3), NPC2 is a secreted protein mapping against gene 14q24 |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Synonyms: |
HE1 NP-C2 EDDM1 |
| Properties: |
Avidin and Streptavidin bind to the small biotin and are couple to HRP or AP for ELISA, Biotin conjugates can be detected by horseradish peroxidase, To break the streptavidin Biotin bond we suggest to use a 6 molar guanidine HCl solution with acidity of pH 1, alkaline phosphatase substrates or anti biotin conjugated antibodies, 6, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
NPC2/Niemann Pick C2 Conjugated |
| Short name: |
Conjugated, NPC2/Niemann Pick C2 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label: |
Biotin |
| Alternative name: |
biotinilated coupled, NPC2/Niemann Pick complement component 2 (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
ARMD14 and CO2, C2 and IDBG-124824 and ENSG00000166278 and 101928623, C2 and IDBG-174547 and ENSMUSG00000024371 and 12263, C2 and IDBG-633680 and ENSBTAG00000007450 and 515440, Extracellular, classical pathway and biological process this GO :0007584 and response to nutrient and biological process this GO :0030449 and regulation of complement activation and biological process this GO :0045087 and innate immune response and biological process this GO :2000427 and positive regulation of apoptotic cell clearance and biological process, protein binding, this GO :0003824 and catalytic activity and molecular function this GO :0004252 and serine-type endopeptidase activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005576 and extracellular region and cellular component this GO :0005615 and extracellular space and cellular component this GO :0006508 and proteolysis and biological process this GO :0006956 and complement activation and biological process this GO :0006958 and complement activation, this GO :0003824 : catalytic activity, this GO :0003824 : catalytic activity and also this GO :0004252 : serine-type endopeptidase activity and also this GO :0005515 : protein binding, this GO :0004252 : serine-type endopeptidase activity, this GO :0005515 : protein binding, 717, complement component 2 |
| Identity: |
14537 |
| Gene: |
NPC2 |
More about : NPC2 |
| Long gene name: |
NPC intracellular cholesterol transporter 2 |
| Synonyms gene name: |
Niemann-Pick disease, type C2 |
| Synonyms name: |
epididymal protein 1 |
| Locus: |
14q24, 3 |
| Discovery year: |
2001-05-11 |
| GenBank acession: |
X67698 |
| Entrez gene record: |
10577 |
| Pubmed identfication: |
8418812 11125141 |
| RefSeq identity: |
NM_006432 |
| Havana BLAST/BLAT: |
OTTHUMG00000171212 |