| Category: |
Antibody |
| Concentration: |
pH 7, with 0, 09% sodium azide, 4, In 1X PBS |
| Form: |
Purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
SMAD7 |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
ELISA, IF, IHC, WB |
| Recommended dilutions: |
IHC (Paraffin): 1:10-1:50, Immunofluorescence: 1:10-1:50, Western blot: 1:1000 |
| Notes: |
Titration of the SMAD7 antibody may be required due to differences in protocols and secondary/substrate sensitivity |
| Intented use: |
This SMAD7 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
O15105 |
| Purity: |
Purified |
| Description: |
MAD-related proteins are a recently identified family of intracellular proteins that are thought to be essential components in the signaling pathways of the serine/threonine kinase receptors of the transforming growth factor beta super family, SMAD7 is a member of the MAD-related family of molecules |
| Immunogen: |
A portion of amino acids 195-224 from the human protein was used as the immunogen for this SMAD7 antibody |
| Storage: |
Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the SMAD7 antibody and store frozen at -20 deg |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
SMAD7 |
| Short name: |
SMAD7 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
SMAD family member 7 (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
CRCS3 and MADH7 and MADH8, DNA-templated and biological process this GO :0006355 and regulation of transcription, DNA-templated and biological process this GO :0006367 and transcription initiation from RNA polymerase II promoter and biological process this GO :0007179 and transforming growth factor beta receptor signaling pathway and biological process this GO :0008013 and beta-catenin binding and molecular function this GO :0010467 and gene expression and biological process this GO :0010719 and negative regulation of epithelial to mesenchymal transition and biological process this GO :0010801 and negative regulation of peptidyl-threonine phosphorylation and biological process this GO :0010944 and negative regulation of transcription by competitive promoter binding and biological process this GO :0016342 and catenin complex and cellular component this GO :0017015 and regulation of transforming growth factor beta receptor signaling pathway and biological process this GO :0022409 and positive regulation of cell-cell adhesion and biological process this GO :0030336 and negative regulation of cell migration and biological process this GO :0030509 and BMP signaling pathway and biological process this GO :0030512 and negative regulation of transforming growth factor beta receptor signaling pathway and biological process this GO :0030514 and negative regulation of BMP signaling pathway and biological process this GO :0030617 and transforming growth factor beta receptor, DNA-templated and biological process this GO :0045944 and positive regulation of transcription from RNA polymerase II promoter and biological process this GO :0046872 and metal ion binding and molecular function this GO :0048185 and activin binding and molecular function this GO :0048844 and artery morphogenesis and biological process this GO :0050821 and protein stabilization and biological process this GO :0051444 and negative regulation of ubiquitin-protein transferase activity and biological process this GO :0055010 and ventricular cardiac muscle tissue morphogenesis and biological process this GO :0055117 and regulation of cardiac muscle contraction and biological process this GO :0060373 and regulation of ventricular cardiac muscle cell membrane depolarization and biological process this GO :0060389 and pathway-restricted SMAD protein phosphorylation and biological process this GO :0060394 and negative regulation of pathway-restricted SMAD protein phosphorylation and biological process this GO :0060412 and ventricular septum morphogenesis and biological process this GO :0070411 and I-SMAD binding and molecular function this GO :0071560 and cellular response to transforming growth factor beta stimulus and biological process, SMAD7 and IDBG-3195 and ENSG00000101665 and 4092, SMAD7 and IDBG-644653 and ENSBTAG00000012441 and 535916, Smad7 and IDBG-158890 and ENSMUSG00000025880 and 17131, inhibitory cytoplasmic mediator activity, inhibitory cytoplasmic mediator activity and also this GO :0031625 : ubiquitin protein ligase binding and also this GO :0034713 : type I transforming growth factor beta receptor binding and also this GO :0044212 : transcription regulatory region DNA binding and also this GO :0046872 : metal ion binding and also this GO :0048185 : activin binding and also this GO :0070411 : I-SMAD binding, inhibitory cytoplasmic mediator activity and molecular function this GO :0031397 and negative regulation of protein ubiquitination and biological process this GO :0031398 and positive regulation of protein ubiquitination and biological process this GO :0031625 and ubiquitin protein ligase binding and molecular function this GO :0032436 and positive regulation of proteasomal ubiquitin-dependent protein catabolic process and biological process this GO :0032925 and regulation of activin receptor signaling pathway and biological process this GO :0033137 and negative regulation of peptidyl-serine phosphorylation and biological process this GO :0034333 and adherens junction assembly and biological process this GO :0034616 and response to laminar fluid shear stress and biological process this GO :0034629 and cellular protein complex localization and biological process this GO :0034713 and type I transforming growth factor beta receptor binding and molecular function this GO :0035556 and intracellular signal transduction and biological process this GO :0043234 and protein complex and cellular component this GO :0043433 and negative regulation of sequence-specific DNA binding transcription factor activity and biological process this GO :0044212 and transcription regulatory region DNA binding and molecular function this GO :0045087 and innate immune response and biological process this GO :0045892 and negative regulation of transcription, nuclei, this GO :0000122 and negative regulation of transcription from RNA polymerase II promoter and biological process this GO :0001657 and ureteric bud development and biological process this GO :0003700 and sequence-specific DNA binding transcription factor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005518 and collagen binding and molecular function this GO :0005622 and intracellular and cellular component this GO :0005634 and nucleus and cellular component this GO :0005654 and nucleoplasm and cellular component this GO :0005667 and transcription factor complex and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005829 and cytosol and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0005913 and cell-cell adherens junction and cellular component this GO :0006351 and transcription, this GO :0003700 : sequence-specific DNA binding transcription factor activity, this GO :0003700 : sequence-specific DNA binding transcription factor activity and also this GO :0005515 : protein binding and also this GO :0005518 : collagen binding and also this GO :0008013 : beta-catenin binding and also this GO :0030617 : transforming growth factor beta receptor, this GO :0005515 : protein binding, this GO :0005518 : collagen binding, this GO :0008013 : beta-catenin binding, this GO :0030617 : transforming growth factor beta receptor, this GO :0031625 : ubiquitin protein ligase binding, this GO :0034713 : type I transforming growth factor beta receptor binding, this GO :0044212 : transcription regulatory region DNA binding, this GO :0046872 : metal ion binding, this GO :0048185 : activin binding, this GO :0070411 : I-SMAD binding, transforming growth factor beta receptor, SMAD family member 7 |
| Identity: |
6773 |
| Gene: |
SMAD7 |
More about : SMAD7 |
| Long gene name: |
SMAD family member 7 |
| Synonyms gene: |
MADH8 MADH7 |
| Synonyms gene name: |
MAD, mothers against DPP homolog 7 (Drosophila) , mothers against decapentaplegic homolog 7 (Drosophila) SMAD |
| Locus: |
18q21, 1 |
| Discovery year: |
1997-08-22 |
| GenBank acession: |
AF010193 |
| Entrez gene record: |
4092 |
| Pubmed identfication: |
9256479 9730599 |
| RefSeq identity: |
NM_005904 |
| Classification: |
SMAD family |
| Havana BLAST/BLAT: |
OTTHUMG00000132655 |