| Also known as: |
IL10 |
| Other names: |
CSIF, Cytokine synthesis inhibitory factor, Interleukin-10, T-cell growth inhibitory factor, cytokine synthesis inhibitory factor, interleukin 10, interleukin-10, interleukin-10 |
| Category: |
Antibodies |
| Subcategory: |
Mnoclonal antibodies |
| Gene name: |
IL10 |
| Other gene names: |
CSIF, CSIF, GVHDS, IL-10, IL-10, IL10, IL10A, TGIF, IL10 |
| Clonality: |
Monoclonal |
| Immunoglobulin isotype: |
IgG1 |
| Clone: |
JES5-2A5 |
| Host organism: |
Rat (Rattus norvegicus) |
| Species reactivity: |
Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby, Mouse (Mus musculus) |
| Specificity and cross-reactivity: |
IL-10 is expressed by Ly-1 (B-1) B cells that express CD5 (Ly-1) and a subset of lectin stimulated T cells, Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited, This particular antibody might cross react with speacies outside of the listed ones, Recognizes mouse Interleukin-10 (IL-10) |
| Purification method: |
Protein G Purified |
| Form/Appearance: |
0, pH 7, 09% sodium azide, 4, PBS |
| Concentration: |
1 miligram per 1 mililiter |
| Storage and shipping: |
Cycles of freezing and defrosting may denaturate the polypeptide chains of the antibodies and reduce their activity, For longer storage the antibody should be kept at -20 degrees Celsius, For short term storage keep the antibody at +4 degrees Celsius |
| Tested applications:: |
ELISA (EIA), Flow Cytometry (FC/FACS), IHC - Frozen), Western Blot (WB), Immunohistochemistry (IHC - Paraffin |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by MBS mono they should be stored frozen at - 24° |
| Gene: |
IL10 |
More about : IL10 |
| About: |
Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Rats are used to make rat monoclonal anti mouse antibodies, Rats , There are less rat- than mouse clones however, Monoclonals of this antigen are available in different clones, Rattus norvegicus are often studied in vivo as a model of human genes in Sprague-Dawley or Wistar rats, genes from rodents , of the genus |
| Test: |
A/J, BALB/c, Mouse are mature after 40 days for females and 55 days for males, SCID while the CD-1 is outbred as strain, The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year, Transgenic, congenic and inbread strains are known for C57BL/6, knock-out, Mouse , mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab, or |
| Latin name: |
Rattus norvegicus, Mus musculus |
| Gene target: |
Monoclonal [ JES5-2A5] (IgG1) IL10 |
| Short name: |
Monoclonal [clone JES5-2A5] (IgG1) Mouse IL10 Antibody |
| Technique: |
Monoclonals or monoclonal antibodies, antibodies against human proteins, antibodies for, mouses, Antibody |
| Host: |
Rat |
| Isotype: |
IgG1 |
| Species: |
Mouses, Rats, Mouse |
| Alternative name: |
Rat monoclonal [clonality JES5-2A5] (IgG1) to Mouse interleukin 10 (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
CSIF and GVHDS and IL-10 and IL10A and TGIF, DNA-templated and biological process this GO :0045944 and positive regulation of transcription from RNA polymerase II promoter and biological process this GO :0050715 and positive regulation of cytokine secretion and biological process this GO :0050728 and negative regulation of inflammatory response and biological process this GO :0051045 and negative regulation of membrane protein ectodomain proteolysis and biological process this GO :0051091 and positive regulation of sequence-specific DNA binding transcription factor activity and biological process this GO :0051384 and response to glucocorticoid and biological process this GO :0051930 and regulation of sensory perception of pain and biological process this GO :0060670 and branching involved in labyrinthine layer morphogenesis and biological process this GO :0071222 and cellular response to lipopolysaccharide and biological process this GO :0071392 and cellular response to estradiol stimulus and biological process, Extracellular, IL10 and IDBG-106270 and ENSG00000136634 and 3586, IL10 and IDBG-629159 and ENSBTAG00000006685 and 281246, Il10 and IDBG-190697 and ENSMUSG00000016529 and 16153, growth factor activity, this GO :0001818 and negative regulation of cytokine production and biological process this GO :0002237 and response to molecule of bacterial origin and biological process this GO :0002740 and negative regulation of cytokine secretion involved in immune response and biological process this GO :0002875 and negative regulation of chronic inflammatory response to antigenic stimulus and biological process this GO :0002904 and positive regulation of B cell apoptotic process and biological process this GO :0005125 and cytokine activity and molecular function this GO :0005141 and interleukin-10 receptor binding and molecular function this GO :0005615 and extracellular space and cellular component this GO :0006954 and inflammatory response and biological process this GO :0006955 and immune response and biological process this GO :0007253 and cytoplasmic sequestering of NF-kappaB and biological process this GO :0007267 and cell-cell signaling and biological process this GO :0007568 and aging and biological process this GO :0008083 and growth factor activity and molecular function this GO :0010033 and response to organic substance and biological process this GO :0010468 and regulation of gene expression and biological process this GO :0014823 and response to activity and biological process this GO :0014854 and response to inactivity and biological process this GO :0030097 and hemopoiesis and biological process this GO :0030183 and B cell differentiation and biological process this GO :0030595 and leukocyte chemotaxis and biological process this GO :0030886 and negative regulation of myeloid dendritic cell activation and biological process this GO :0030889 and negative regulation of B cell proliferation and biological process this GO :0032496 and response to lipopolysaccharide and biological process this GO :0032689 and negative regulation of interferon-gamma production and biological process this GO :0032695 and negative regulation of interleukin-12 production and biological process this GO :0032715 and negative regulation of interleukin-6 production and biological process this GO :0032720 and negative regulation of tumor necrosis factor production and biological process this GO :0032800 and receptor biosynthetic process and biological process this GO :0032868 and response to insulin and biological process this GO :0034465 and response to carbon monoxide and biological process this GO :0042092 and type 2 immune response and biological process this GO :0042100 and B cell proliferation and biological process this GO :0042130 and negative regulation of T cell proliferation and biological process this GO :0042493 and response to drug and biological process this GO :0042536 and negative regulation of tumor necrosis factor biosynthetic process and biological process this GO :0042742 and defense response to bacterium and biological process this GO :0043066 and negative regulation of apoptotic process and biological process this GO :0044130 and negative regulation of growth of symbiont in host and biological process this GO :0045019 and negative regulation of nitric oxide biosynthetic process and biological process this GO :0045087 and innate immune response and biological process this GO :0045191 and regulation of isotype switching and biological process this GO :0045347 and negative regulation of MHC class II biosynthetic process and biological process this GO :0045348 and positive regulation of MHC class II biosynthetic process and biological process this GO :0045355 and negative regulation of interferon-alpha biosynthetic process and biological process this GO :0045893 and positive regulation of transcription, this GO :0005125 : cytokine activity, this GO :0005125 : cytokine activity and also this GO :0005141 : interleukin-10 receptor binding and also this GO :0008083 : growth factor activity, this GO :0005141 : interleukin-10 receptor binding, this GO :0008083 : growth factor activity, interleukin 10 |
| Identity: |
5962 |
| Long gene name: |
interleukin 10 |
| Synonyms: |
CSIF TGIF IL10A IL-10 |
| Synonyms name: |
cytokine synthesis inhibitory factor T-cell growth inhibitory factor |
| Locus: |
1q32, 1 |
| Discovery year: |
1991-10-31 |
| GenBank acession: |
M57627 |
| Entrez gene record: |
3586 |
| Pubmed identfication: |
9162098 |
| RefSeq identity: |
NM_000572 |
| Classification: |
Interleukins |
| Havana BLAST/BLAT: |
OTTHUMG00000036386 |