| Long name: |
ALEXA FLUOR 350 Conjugated, KRIT1 Polyclonal Antibody |
| Also known as: |
Anti-KRIT1 PAb ALEXA FLUOR 350 |
| Category: |
Conjugated Primary Antibodies |
| Conjugated with: |
350, ALEXA FLUOR® |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
KRIT1 |
| Specificity: |
This is a highly specific antibody against KRIT1 |
| Modification: |
Unmodified |
| Modification Site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
650-700/736 |
| Subcellular location: |
Cell membrane |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human KRIT1 |
| Gene ID Number: |
889 |
| Swiss Prot: |
O00522 |
| Tested applications: |
IF(IHC-P), FCM |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), FCM(1:20-100) |
| Crossreactivity: |
Mouse, Rat, Human |
| Cross-reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen: |
Acts in concert with CDH5 to establish and maintain correct endothelial cell polarity and vascular lumen and these effects are mediated by recruitment and activation of the Par polarity complex and RAP1B, Facilitates the down-regulation of cyclin-D1 (CCND1) levels required for cell transition from proliferative growth to quiescence by preventing the accumulation of intracellular ROS through the modulation of FOXO1 and SOD2 levels, Inhibits endothelial proliferation, Microtubule-associated protein that binds to phosphatidylinositol 4, Negative regulator of angiogenesis, PARD3, Plays a role in integrin signaling via its interaction with ITGB1BP1, Plays an important role in the maintenance of the intracellular reactive oxygen species (ROS) homeostasis to prevent oxidative cellular damage, Promotes AKT phosphorylation in a NOTCH-dependent and independent manner, Regulates the homeostasis of intracellular ROS through an antioxidant pathway involving FOXO1 and SOD2, Required for the localization of phosphorylated PRKCZ, TIAM1 and RAP1B to the cell junction, and cell junction stabilization, and inhibits ERK1/2 phosphorylation indirectly through activation of the DELTA-NOTCH cascade, apoptosis, lumen formation and sprouting angiogenesis in primary endothelial cells, migration, this prevents the interaction between ITGB1 and ITGB1BP1, 5-bisphosphate (PIP2)-containing membranes in a GTP-bound RAP1-dependent manner, Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity (By similarity) |
| Purification: |
Purified by Protein A |
| Storage conditions: |
50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission: |
343nm/442nm |
| Synonyms: |
CAM |
| Properties: |
ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 350 conjugates can be used in multi-color flow cytometry with FACS's equipped with a second red laser or red diode, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
ALEXA FLUOR 350, Alexa Fluor |
| Gene target: |
KRIT1 |
| Short name: |
KRIT1 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Label: |
ALEXA FLUOR 350 |
| Alternative name: |
ALEXA FLUOR 350, KRIT1 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
1573 |
| Gene: |
KRIT1 |
More about : KRIT1 |
| Long gene name: |
KRIT1, ankyrin repeat containing |
| Synonyms gene: |
CCM1 |
| Synonyms gene name: |
cerebral cavernous malformations 1 |
| Locus: |
7q21, 2 |
| Discovery year: |
1995-06-02 |
| GenBank acession: |
AJ294850 |
| Entrez gene record: |
889 |
| Pubmed identfication: |
7604043 11342228 |
| Classification: |
Ankyrin repeat domain containing FERM domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000131187 |
| Locus Specific Databases: |
LRG_650 |