| Long name: |
KRIT1 Primary Polyclonal Antibody |
| Also known as: |
KRIT1 PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
KRIT1 |
| Specificity: |
This is a highly specific antibody against KRIT1 |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
650-700/736 |
| Subcellular location: |
Cell membrane |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human KRIT1 |
| Gene ID number: |
889 |
| Swiss Prot: |
O00522 |
| Tested Applications: |
FCM, IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
FCM(1:20-100), IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Acts in concert with CDH5 to establish and maintain correct endothelial cell polarity and vascular lumen and these effects are mediated by recruitment and activation of the Par polarity complex and RAP1B, Facilitates the down-regulation of cyclin-D1 (CCND1) levels required for cell transition from proliferative growth to quiescence by preventing the accumulation of intracellular ROS through the modulation of FOXO1 and SOD2 levels, Inhibits endothelial proliferation, Microtubule-associated protein that binds to phosphatidylinositol 4, Negative regulator of angiogenesis, PARD3, Plays a role in integrin signaling via its interaction with ITGB1BP1, Plays an important role in the maintenance of the intracellular reactive oxygen species (ROS) homeostasis to prevent oxidative cellular damage, Promotes AKT phosphorylation in a NOTCH-dependent and independent manner, Regulates the homeostasis of intracellular ROS through an antioxidant pathway involving FOXO1 and SOD2, Required for the localization of phosphorylated PRKCZ, TIAM1 and RAP1B to the cell junction, and cell junction stabilization, and inhibits ERK1/2 phosphorylation indirectly through activation of the DELTA-NOTCH cascade, apoptosis, lumen formation and sprouting angiogenesis in primary endothelial cells, migration, this prevents the interaction between ITGB1 and ITGB1BP1, 5-bisphosphate (PIP2)-containing membranes in a GTP-bound RAP1-dependent manner, Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity (By similarity) |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
CCM1, Cerebral cavernous malformations 1 protein, KRIT1, Krev interaction trapped 1, Krev interaction trapped protein 1, CAM |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
KRIT1 |
| Short name: |
KRIT1 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
KRIT1 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
1573 |
| Gene: |
KRIT1 |
More about : KRIT1 |
| Long gene name: |
KRIT1, ankyrin repeat containing |
| Synonyms gene: |
CCM1 |
| Synonyms gene name: |
cerebral cavernous malformations 1 |
| Synonyms: |
CAM |
| Locus: |
7q21, 2 |
| Discovery year: |
1995-06-02 |
| GenBank acession: |
AJ294850 |
| Entrez gene record: |
889 |
| Pubmed identfication: |
7604043 11342228 |
| Classification: |
Ankyrin repeat domain containing FERM domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000131187 |
| Locus Specific Databases: |
LRG_650 |