| Long name: |
ALEXA FLUOR 594 Conjugated, Optineurin Polyclonal Antibody |
| Also known as: |
Anti-Optineurin PAb ALEXA FLUOR 594 |
| Category: |
Conjugated Primary Antibodies |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
Optineurin |
| Specificity: |
This is a highly specific antibody against Optineurin |
| Modification: |
Unmodified |
| Modification Site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
350-400/577 |
| Subcellular location: |
Cytoplasm |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Optineurin |
| Gene ID Number: |
10133 |
| Swiss Prot: |
Q96CV9 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Human |
| Cross-reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen: |
Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family, Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation, May act by regulating membrane trafficking and cellular morphogenesis via a complex that contains Rab8 and hungtingtin (HD), May constitute a cellular target for adenovirus E3 14, Mediates the interaction of Rab8 with the probable GTPase-activating protein TBC1D17 during Rab8-mediated endocytic trafficking, Negatively regulates the induction of IFNB in response to RNA virus infection, Plays a neuroprotective role in the eye and optic nerve, Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death, an inhibitor of TNF-alpha functions, and appears to function in the same pathway as SQSTM1 and CALCOCO2/NDP52, in exocytosis, in membrane trafficking, regulates Rab8 recruitnment to tubules emanating from the endocytic recycling compartment, such as cytoplasmic Salmonella enterica, such as of transferrin receptor (TFRC/TfR), targets ubiquitin-coated bacteria (xenophagy), thereby affecting cell death, through its interaction with myosin VI and Rab8, 7, Plays an important role in the maintenance of the Golgi complex |
| Purification: |
Purified by Protein A |
| Storage conditions: |
50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
FIP2 HYPL FIP-2 TFIIIA-INTP NRP HIP7 |
| Properties: |
ALEXA FLUOR they should be stored frozen at - 24°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
594, ALEXA FLUOR®, Alexa Fluor |
| Conjugated: |
Alexa conjugate 1 |
| Gene target: |
Optineurin |
| Short name: |
Optineurin Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Label: |
ALEXA FLUOR 594 |
| Alternative name: |
ALEXA FLUOR 594, Optineurin (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
17142 |
| Gene: |
OPTN |
More about : OPTN |
| Long gene name: |
optineurin |
| Synonyms gene: |
GLC1E |
| Synonyms gene name: |
E (adult-onset) , glaucoma 1, open angle |
| Locus: |
10p13 |
| Discovery year: |
2001-11-16 |
| GenBank acession: |
AF420371 |
| Entrez gene record: |
10133 |
| Pubmed identfication: |
11834836 9488477 |
| RefSeq identity: |
NM_021980 |
| Havana BLAST/BLAT: |
OTTHUMG00000017690 |
| Locus Specific Databases: |
ALSOD, the Amyotrophic Lateral Sclerosis Online Genetic Database |