| Long name: |
Cy3 Conjugated, IFI30 Polyclonal Antibody |
| Category: |
Conjugated Primary Antibodies |
| Conjugation: |
cy3 conjugation kit |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
I30 |
| Specificity: |
This is a highly specific antibody against I30 |
| Modification: |
Unmodified |
| Modification site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
KLH conjugated synthetic peptide derived from human IFI30 |
| Gene ID number: |
10437 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Crossreactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background: |
A lysosomal thiol reductase, Additionally, Cytosolic reduction is mediated enzymatically by thioredoxin, Efficient proteolysis requires denaturation, GILT, GILT is expressed constitutively in antigen-presenting cells and is induced by g-interferon in other cell types, GILT is synthesized as a precursor, In the endocytic pathway, T cell recognition of select exogenous and endogenous epitopes is dependent on tumor cell expression of GILT, The absence of GILT in melanomas alters antigen processing and the hierarchy of immunodominant epitope presentation, This process is catalyzed by a gamma-interferon-inducible thiol reductase (GILT), and following delivery to MHC class II-containing compartments (MIICs), and reduction of inter- and intrachain disulfide bonds, induced by acidic conditions within lysosomes, is optimally active at low pH and capable of catalyzing disulfide bond reduction both in vivo and in vitro, is processed to the mature form via cleavage of amino- and carboxy-terminal propeptides, reduction of protein disulfide bonds is important for the generation of MHC class II-peptide complexes, suggesting a potentially important role in antigen processing, Proteins internalized into the endocytic pathway are usually degraded |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Excitation Emission: |
512, 550nm/570, 615nm |
| Synonyms: |
IFI-30 GILT IP30 MGC32056 IP-30 |
| Properties: |
1 of the IFI30 Antibody, Conjugated can be used in flow cytometry but typically shows lower fluorescence intensity comparable to that of PE or APC, Cy3 antibodies are excited by the 488-nanometer wave of an argon laser and the 633-nanometer line of a helium-neon diode laser, This Bioss Primary Conjugated Antibodies antibody is well suited for fluorescent microscopy, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
IFI30 Conjugated |
| Short name: |
Conjugated, IFI30 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label: |
Cy3 |
| Alternative name: |
cyanine 3 coupled, gamma-inducible protein 30 (Antibody to), interferon |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
Extracellular, GILT and IFI-30 and IP30, IFI30 and IDBG-281623 and ENSG00000216490 and 10437, IFI30 and IDBG-641754 and ENSBTAG00000018349 and 615930, Ifi30 and IDBG-164061 and ENSMUSG00000031838 and 65972, acting on a sulfur group of donors, acting on a sulfur group of donors, acting on a sulfur group of donors and molecular function this GO :0019221 and cytokine-mediated signaling pathway and biological process this GO :0019886 and antigen processing and presentation of exogenous peptide antigen via MHC class II and biological process this GO :0030054 and cell junction and cellular component this GO :0042590 and antigen processing and presentation of exogenous peptide antigen via MHC class I and biological process this GO :0043202 and lysosomal lumen and cellular component this GO :0043231 and intracellular membrane-bounded organelle and cellular component this GO :0048147 and negative regulation of fibroblast proliferation and biological process this GO :0050821 and protein stabilization and biological process this GO :0055114 and oxidation-reduction process and biological process this GO :0060333 and interferon-gamma-mediated signaling pathway and biological process, gamma-inducible protein 30, oxidoreductase activity, this GO :0005576 and extracellular region and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005764 and lysosome and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0016667 and oxidoreductase activity, this GO :0016667 : oxidoreductase activity, this GO :0016667 : oxidoreductase activity, interferon |
| Identity: |
5398 |
| Gene: |
IFI30 |
More about : IFI30 |
| Long gene name: |
IFI30, lysosomal thiol reductase |
| Synonyms gene name: |
interferon gamma inducible protein 30 |
| Synonyms name: |
gamma-interferon-inducible lysosomal thiol reductase interferon gamma-inducible protein 30 preproprotein legumaturain |
| Locus: |
19p13, 11 |
| Discovery year: |
1999-12-09 |
| GenBank acession: |
J03909 |
| Entrez gene record: |
10437 |
| Pubmed identfication: |
3136170 10639150 |
| RefSeq identity: |
NM_006332 |
| Havana BLAST/BLAT: |
OTTHUMG00000183373 |