| Long name: |
FITC Conjugated, GCS1 Polyclonal Antibody |
| Category: |
Conjugated Primary Antibodies |
| Conjugation: |
Anti-FITC Antibody |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
GCS1 |
| Specificity: |
This is a highly specific antibody against GCS1 |
| Modification: |
Unmodified |
| Modification site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
KLH conjugated synthetic peptide derived from human GCS1 |
| Gene ID number: |
7841 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Crossreactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background: |
Glucosidase I catalyzes the first step in the N-linked oligosaccharide processing pathway, Glucosidase I contains a short cytosolic tail, It specifically removes the distal alpha 1, Mutations in the gene encoding Glucosidase I result in the congenital disorder glycosylation (CDG-IIb), Two point mutations in the Glucosidase I gene have been identified and result in amino acid substitutions, a single pass transmembrane domain and a large C-terminal catalytic domain located on the luminal side of the ER, dysmorphic features, feeding problems, hepatomegaly, hypoventilation, namely Arg486Thr and Phe652Leu, seizures and death, that affect polypeptide folding and active site formation, which is characterized by generalized hypotonia, 2-linked glucose residue from the Glc3-Man9-GlcNAc2 oligosaccharide precursor, Glycosylation of asparagine residues in Asn-X-Ser/Thr motifs in proteins commonly occur in the lumen of the endoplasmic reticulum (ER) |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Excitation Emission: |
494nm/518nm |
| Synonyms: |
GCS1 CWH41 DER7 |
| Properties: |
Bioss Primary Conjugated Antibodies FITC is highly sensitive to pH extremes, FITC has a green emission that's usually collected at 530 nanometers, FITC has a high quantum yield (efficiency of energy transfer from absorption to emission fluorescence) and approximately half of the absorbed photons are emitted as fluorescent light, For fluorescent microscopy applications, This Bioss Primary Conjugated Antibodies Fluorescein isothiocyanate (FITC) antibody is currently after some BD antibodies the most commonly used fluorescent dye for FACS, When excited at 488 nanometers, its photo bleaching effects are not observed due to a very brief interaction at the laser intercept, the 1 FITC is seldom used as it photo bleaches rather quickly though in flow cytometry applications, the FL1 detector of a FACSCalibur or FACScan, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
GCS1 Conjugated |
| Short name: |
FITC Conjugated, GCS1 Antibody |
| Technique: |
Fluorescein, antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label: |
FITC |
| Alternative name: |
fluorecein coupled, GCS1 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
24862 |
| Gene: |
MOGS |
More about : MOGS |
| Long gene name: |
mannosyl-oligosaccharide glucosidase |
| Synonyms name: |
glucosidase I processing A-glucosidase I |
| Locus: |
2p13, 1 |
| Discovery year: |
2009-03-24 |
| GenBank acession: |
X87237 |
| Entrez gene record: |
7841 |
| Pubmed identfication: |
7635146 8786151 |
| RefSeq identity: |
NM_006302 |
| Havana BLAST/BLAT: |
OTTHUMG00000152886 |