| Long name: |
Biotin Conjugated, GCDH Polyclonal Antibody |
| Category: |
Conjugated Primary Antibodies |
| Conjugation: |
Biotinylated |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
GCDH |
| Specificity: |
This is a highly specific antibody against GCDH |
| Modification: |
Unmodified |
| Modification site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
KLH conjugated synthetic peptide derived from human GCDH |
| Gene ID number: |
2639 |
| Tested applications: |
IHC-P, WB |
| Recommended dilutions: |
IHC-P(1:100-500), WB(1:100-1000) |
| Crossreactivity: |
Mouse, Rat, Human |
| Crossreactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background: |
Defects in the gene encoding GCDH are the cause of glutaric acidemia type I (GA-I), Existing as a homotetramer, GCDH uses FAD as a cofactor to catalyze the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and CO(2) in the degradative pathway of L-lysine, L-hydroxylysine and L-tryptophan metabolism, While GCDH exists as both a long and short isoform, an autosomal recessive disorder that is characterized by the accumulation of glutaconic acid and is associated with such symptoms as progressive dystonia and athetosis due to gliosis and neuronal loss in the basal ganglia, only the long isoform is a functionally active protein, GCDH is a 438 amino acid protein that localizes to the mitochondrial matrix and belongs to the acyl-CoA dehydrogenase family |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Synonyms: |
ACAD5 |
| Properties: |
Avidin and Streptavidin bind to the small biotin and are couple to HRP or AP for ELISA, Biotin conjugates can be detected by horseradish peroxidase, To break the streptavidin Biotin bond we suggest to use a 6 molar guanidine HCl solution with acidity of pH 1, alkaline phosphatase substrates or anti biotin conjugated antibodies, 6, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
GCDH Conjugated |
| Short name: |
Conjugated, GCDH Antibody |
| Technique: |
antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label: |
Biotin |
| Alternative name: |
biotinilated coupled, GCDH (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
4189 |
| Gene: |
GCDH |
More about : GCDH |
| Long gene name: |
glutaryl-CoA dehydrogenase |
| Synonyms gene name: |
glutaryl-Coenzyme A dehydrogenase |
| Locus: |
19p13, 13 |
| Discovery year: |
1992-12-17 |
| GenBank acession: |
AF012342 |
| Entrez gene record: |
2639 |
| Pubmed identfication: |
1438360 8088809 |
| Classification: |
Acyl-CoA dehydrogenase family |
| Havana BLAST/BLAT: |
OTTHUMG00000180561 |