| Long name: |
GCDH Primary Polyclonal Antibody |
| Also known as: |
GCDH PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
GCDH |
| Specificity: |
This is a highly specific antibody against GCDH |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human GCDH |
| Gene ID number: |
2639 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Defects in the gene encoding GCDH are the cause of glutaric acidemia type I (GA-I), Existing as a homotetramer, GCDH uses FAD as a cofactor to catalyze the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and CO(2) in the degradative pathway of L-lysine, L-hydroxylysine and L-tryptophan metabolism, While GCDH exists as both a long and short isoform, an autosomal recessive disorder that is characterized by the accumulation of glutaconic acid and is associated with such symptoms as progressive dystonia and athetosis due to gliosis and neuronal loss in the basal ganglia, only the long isoform is a functionally active protein, GCDH is a 438 amino acid protein that localizes to the mitochondrial matrix and belongs to the acyl-CoA dehydrogenase family |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
EC 1, GCD, GCDH_HUMAN, Gcdh, Glutaryl CoA dehydrogenase, Glutaryl Coenzyme A dehydrogenase, Glutaryl-CoA dehydrogenase, MS781, mitochondrial, mitochondrial, 3, 7, 99, ACAD5 |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
GCDH |
| Short name: |
GCDH Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
GCDH (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
4189 |
| Gene: |
GCDH |
More about : GCDH |
| Long gene name: |
glutaryl-CoA dehydrogenase |
| Synonyms gene name: |
glutaryl-Coenzyme A dehydrogenase |
| Synonyms: |
ACAD5 |
| Locus: |
19p13, 13 |
| Discovery year: |
1992-12-17 |
| GenBank acession: |
AF012342 |
| Entrez gene record: |
2639 |
| Pubmed identfication: |
1438360 8088809 |
| Classification: |
Acyl-CoA dehydrogenase family |
| Havana BLAST/BLAT: |
OTTHUMG00000180561 |