| Long name: |
GAMT Primary Polyclonal Antibody |
| Also known as: |
GAMT PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
GAMT |
| Specificity: |
This is a highly specific antibody against GAMT |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
150-200/236 |
| Subcellular location: |
Cytoplasm |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human GAMT |
| Gene ID number: |
2593 |
| Swiss Prot: |
Q14353 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Defects in the GAMT gene leads to GAMT deficiency, Encoding a 236 amino acid protein, GAMT, Methyltransferases are a type of transferase enzyme which transfers a methyl group to nucleic bases in DNA or amino acids in protein, Such biochemical changes are thought to lead to various neurological syndromes and muscular hypotonia, a methyltransferase, and guanidinoacetate is then converted to creatine by Guanidinoacetate N-methyltransferase (GAMT), glycine is converted to guanidinoacetate by amidinotransferase, the human GAMT gene maps to chromosome 19p13, uses S-adenosylmethionine as the methyl donor for this reaction, which is associated with guanidinoacetate accumulation and decreased levels of creatine excretion in brain, 3, In the creatine biosynthesis pathway |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
CCDS2, GAMT, Guanidinoacetate N-methyltransferase, HEL-S-20, TP53I2, PIG2 |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
GAMT |
| Short name: |
GAMT Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
GAMT (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
4136 |
| Gene: |
GAMT |
More about : GAMT |
| Long gene name: |
guanidinoacetate N-methyltransferase |
| Synonyms: |
PIG2 TP53I2 |
| Locus: |
19p13, 3 |
| Discovery year: |
1996-07-19 |
| GenBank acession: |
Z49878 |
| Entrez gene record: |
2593 |
| Pubmed identfication: |
9570966 8547310 |
| RefSeq identity: |
NM_138924 |
| Havana BLAST/BLAT: |
OTTHUMG00000180095 |
| Locus Specific Databases: |
LOVD - Leiden Open Variation Database |