| Long name: |
FITC Conjugated, CCL5/RANTES Polyclonal Antibody |
| Category: |
Conjugated Primary Antibodies |
| Conjugation: |
Anti-FITC Antibody |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
CCL5/RANTES |
| Specificity: |
This is a highly specific antibody against CCL5/RANTES |
| Modification: |
Unmodified |
| Modification site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen_range: |
71-89/91 |
| Subcellular location: |
Helical, Secreted |
| Source: |
KLH conjugated synthetic peptide derived from human CCL5 |
| Gene ID number: |
6352 |
| Swiss Prot: |
P13501 |
| Tested applications: |
IF(IHC-P), FCM |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), FCM(1:20-100) |
| Crossreactivity: |
Bovine, Mouse, Human |
| Crossreactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background: |
Akt and MAP kinases, By activating GPR75 may also play a role in insulin secretion by islet cells (PubMed:23979485), CCR3, CCR4 and CCR5, Causes the release of histamine from basophils and activates eosinophils, HIV-2, May activate several chemokine receptors including CCR1, May also be an agonist of the G protein-coupled receptor GPR75, One of the major HIV-suppressive factors produced by CD8+ T-cells, PubMed:13864, PubMed:15923218), PubMed:8525373, PubMed:9516414, Recombinant RANTES protein induces a dose-dependent inhibition of different strains of HIV-1, The processed form RANTES(3-68) acts as a natural chemotaxis inhibitor and is a more potent inhibitor of HIV-1-infection, The second processed form RANTES(4-68) exhibits reduced chemotactic and HIV-suppressive activity compared with RANTES(1-68) and RANTES(3-68) and is generated by an unidentified enzyme associated with monocytes and neutrophils (PubMed:1679162, Together with GPR75, and simian immunodeficiency virus (SIV), may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, memory T-helper cells and eosinophils, stimulating inositol trisphosphate production and calcium mobilization through its activation, Chemoattractant for blood monocytes |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Excitation Emission: |
494nm/518nm |
| Synonyms: |
RANTES SISd TCP228 MGC17164 |
| Properties: |
Bioss Primary Conjugated Antibodies FITC is highly sensitive to pH extremes, FITC has a green emission that's usually collected at 530 nanometers, FITC has a high quantum yield (efficiency of energy transfer from absorption to emission fluorescence) and approximately half of the absorbed photons are emitted as fluorescent light, For fluorescent microscopy applications, This Bioss Primary Conjugated Antibodies Fluorescein isothiocyanate (FITC) antibody is currently after some BD antibodies the most commonly used fluorescent dye for FACS, When excited at 488 nanometers, its photo bleaching effects are not observed due to a very brief interaction at the laser intercept, the 1 FITC is seldom used as it photo bleaches rather quickly though in flow cytometry applications, the FL1 detector of a FACSCalibur or FACScan, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
CCL5/RANTES Conjugated |
| Short name: |
FITC Conjugated, CCL5/RANTES Antibody |
| Technique: |
Fluorescein, antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label: |
FITC |
| Alternative name: |
fluorecein coupled, CCL5/RANTES (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
10632 |
| Gene: |
CCL5 |
More about : CCL5 |
| Long gene name: |
C-C motif chemokine ligand 5 |
| Synonyms gene: |
D17S136E SCYA5 |
| Synonyms gene name: |
small inducible cytokine A5 (RANTES) chemokine (C-C motif) ligand 5 |
| Synonyms name: |
T-cell specific protein p288 T-cell specific RANTES protein SIS-delta regulated upon activation, and presumably secreted beta-chemokine RANTES small inducible cytokine subfamily A (Cys-Cys), member 5 , normally T-expressed |
| Locus: |
17q12 |
| Discovery year: |
1990-07-05 |
| GenBank acession: |
AF043341 |
| Entrez gene record: |
6352 |
| Pubmed identfication: |
1691736 |
| RefSeq identity: |
NM_002985 |
| Classification: |
Endogenous ligands Chemokine ligands |
| Havana BLAST/BLAT: |
OTTHUMG00000188396 |