| Long name: |
XAF1 Primary Polyclonal Antibody |
| Also known as: |
XAF1 PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
XAF1 |
| Specificity: |
This is a highly specific antibody against XAF1 |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
170-220/273 |
| Subcellular location: |
Mitochondrion, Nucleus, Cytoplasm |
| Source: |
KLH conjugated synthetic peptide derived from mouse XAF1 |
| Gene ID number: |
327959 |
| Swiss Prot: |
Q5NBU8 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Rat, Mouse |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
After translocation to mitochondra, Induces cleavage and inactivation of BIRC4 independent of caspase activation, Inhibits anti-caspase activity of BIRC4, May be a tumor suppressor by mediating apoptosis resistance of cancer cells (By similarity), May inhibit BIRC4 indirectly by activating the mitochondrial apoptosis pathway, Mediates TNF-alpha-induced apoptosis and is involved in apoptosis in trophoblast cells, Seems to be involved in cellular sensitivity to the proapoptotic actions of TRAIL, Seems to promote the redistribution of BIRC4 from the cytoplasm to the nucleus, The BIRC4-XAF1 complex mediates down-regulation of BIRC5/survivin, probably independent of BIRC4 inactivation which seems to occur in the cytoplasm, promotes translocation of BAX to mitochondria and cytochrome c release from mitochondria, the process requires the E3 ligase activity of BIRC4, Seems to function as a negative regulator of members of the IAP (inhibitor of apoptosis protein) family |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
BIRC4-binding protein, Birc4bp, XIAP-associated factor 1, Xaf1, Xiapaf1, Fbox39 |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
XAF1 |
| Short name: |
XAF1 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
X-linked inhibitor on apoptosis associated factor 1 (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
XAF1 and IDBG-22619 and ENSG00000132530 and 54739, XAF1 and IDBG-633696 and ENSBTAG00000011343 and 509740, Xaf1 and IDBG-196515 and ENSMUSG00000040483 and 327959, nuclei, this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005739 and mitochondrion and cellular component this GO :0005829 and cytosol and cellular component this GO :0006915 and apoptotic process and biological process this GO :0008270 and zinc ion binding and molecular function this GO :0019221 and cytokine-mediated signaling pathway and biological process this GO :0031333 and negative regulation of protein complex assembly and biological process this GO :0035456 and response to interferon-beta and biological process this GO :0060337 and type I interferon signaling pathway and biological process, this GO :0005515 : protein binding, this GO :0005515 : protein binding and also this GO :0008270 : zinc ion binding, this GO :0008270 : zinc ion binding, zinc ion binding, XIAP associated factor 1 |
| Identity: |
30932 |
| Gene: |
XAF1 |
More about : XAF1 |
| Long gene name: |
XIAP associated factor 1 |
| Synonyms: |
BIRC4BP XIAPAF1 HSXIAPAF1 |
| Locus: |
17p13, 2 |
| Discovery year: |
2008-03-04 |
| GenBank acession: |
X99699 |
| Entrez gene record: |
54739 |
| Pubmed identfication: |
12029096 11175744 |
| RefSeq identity: |
NM_017523 |
| Havana BLAST/BLAT: |
OTTHUMG00000177908 |