| Long name: |
DNA Polymerase iota Primary Polyclonal Antibody |
| Also known as: |
DNA Polymerase iota PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
DNA Polymerase iota |
| Specificity: |
This is a highly specific antibody against DNA Polymerase iota |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human DNA Polymerase iota |
| Gene ID number: |
11201 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
At thymine templates, DNA Pol i acts sequentially with DNA Pol Î, DNA Pol i also promotes the replication of damaged DNA by misincorporating deoxynucleotides opposite DNA lesions, DNA Pol i is highly error-prone when replicating undamaged DNA in that it favors the misincorporation of guanine over the correct nucleotide, DNA polymerases can often bypass DNA lesions that block DNA replication, One such DNA polymerase is the distributive enzyme DNA Pol i, POLI is located on human chromosome 18q21, Therefore, a region often implicated in the etiology of many human cancers, adenosine, recombination and mutagenesis, repair, replication involving DNA Pol i is likely to be highly mutagenic, thereby allowing the replication of damaged DNA, to complete the DNA lesion bypass, which is encoded by the POLI gene, which is essential for damage-induced mutagenesis, ©, 2, DNA polymerase activity is essential for replication |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
Eta 2, Eta2, POLI, POLI_HUMAN, Polymerase DNA directed iota, RAD 30B, RAD30 homolog B, RAD30B, RAD3OB, DNA polymerase iota |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
DNA Polymerase iota |
| Short name: |
DNA Polymerase iota Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
Desoxyribonucleic acid polymerizing enzyme iota (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
9815 |
| Gene: |
RAD30B |
More about : RAD30B |
| Long gene name: |
DNA polymerase iota |
| Synonyms gene: |
RAD3OB |
| Synonyms gene name: |
polymerase (DNA directed) iota polymerase (DNA) iota |
| Synonyms: |
POLI |
| Locus: |
18q21, 2 |
| Discovery year: |
2000-01-24 |
| Entrez gene record: |
11201 |
| Pubmed identfication: |
17609217 |
| RefSeq identity: |
NM_007195 |
| Classification: |
DNA polymerases |
| Havana BLAST/BLAT: |
OTTHUMG00000132704 |