| Long name: |
TIE2/CD202b Primary Polyclonal Antibody |
| Also known as: |
TIE2/CD202b PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
TIE2/CD202b |
| Specificity: |
This is a highly specific antibody against TIE2/CD202b |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
450-500/1124 |
| Subcellular location: |
Extracellular |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Tie2 |
| Gene ID number: |
7010 |
| Swiss Prot: |
Q02763 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
ANGPT1 oligomers recruit TEK to cell-cell contacts, ANGPT1 signaling triggers receptor dimerization and autophosphorylation at specific tyrosine residues that then serve as binding sites for scaffold proteins and effectors, ANGPT2 and ANGPT4 and regulates angiogenesis, ANGT1 recruits TEK to contacts with the extracellular matrix, After birth, GRB14, GRB7, Has anti-inflammatory effects by preventing the leakage of proinflammatory plasma proteins and leukocytes from blood vessels, In migrating endothelial cells that lack cell-cell adhesions, In quiescent vessels, Inhibits angiogenesis and promotes vascular stability in quiescent vessels, PIK3R1, Required for normal angiogenesis and heart development during embryogenesis, Required for post-natal hematopoiesis, SHC1 and TIE1, Signaling is also modulated by formation of heterodimers with TIE1, Signaling is modulated by ANGPT2 that has lower affinity for TEK, TEK phosphorylates DOK2, The soluble extracellular domain modulates signaling by functioning as decoy receptor for angiopoietins, activates or inhibits angiogenesis, activation of PTK2/FAK and of the downstream kinases MAPK1/ERK2 and MAPK3/ERK1, adhesion and cell spreading, and by proteolytic processing that gives rise to a soluble TEK extracellular domain, and this leads to preferential activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascades, and ultimately to the stimulation of sprouting angiogenesis, but also maintenance of vascular quiescence, but inhibits ANGPT1-mediated signaling by competing for the same binding site, can promote TEK autophosphorylation in the absence of ANGPT1, depending on the context, endothelial cell survival, forming complexes with TEK molecules from adjoining cells, leading to the formation of focal adhesion complexes, migration, proliferation, reorganization of the actin cytoskeleton, where endothelial cells have tight contacts, Tyrosine-protein kinase that acts as cell-surface receptor for ANGPT1 |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
Angiopoietin-1 receptor, CD22B, Endothelial tyrosine kinase, TEK, TIE-2, Tunica interna endothelial cell kinase, Tyrosine kinase with Ig and EGF homology domains-2, Tyrosine-protein kinase receptor TEK, Tyrosine-protein kinase receptor TIE-2, VMCM, VMCM1, hTIE2, p14 TEK, TIE2 |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
TIE2/CD202b |
| Short name: |
TIE2/CD202b Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
TIE2/CD202b (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
11724 |
| Gene: |
TEK |
More about : TEK |
| Long gene name: |
TEK receptor tyrosine kinase |
| Synonyms gene: |
VMCM |
| Synonyms gene name: |
endothelial , multiple cutaneous and mucosal TEK tyrosine kinase, venous malformations |
| Synonyms: |
TIE2 TIE-2 VMCM1 CD202b |
| Locus: |
9p21, 2 |
| Discovery year: |
1994-05-24 |
| GenBank acession: |
L06139 |
| Entrez gene record: |
7010 |
| Pubmed identfication: |
1312667 7833915 |
| Classification: |
Fibronectin type III domain containing CD molecules Immunoglobulin like domain containing Receptor Tyrosine Kinases |
| Havana BLAST/BLAT: |
OTTHUMG00000019712 |