| Long name: |
ALEXA FLUOR 555 Conjugated, Cytohesin 2 Polyclonal Antibody |
| Also known as: |
Anti-Cytohesin 2 PAb ALEXA FLUOR 555 |
| Category: |
Conjugated Primary Antibodies |
| Conjugated with: |
555, ALEXA FLUOR® |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
Cytohesin 2 |
| Specificity: |
This is a highly specific antibody against Cytohesin 2 |
| Modification: |
Unmodified |
| Modification Site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Cytohesin 2 |
| Gene ID Number: |
9266 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Cross-reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen: |
A small group of GEFs which are insensitive to brefeldin-A (BFA) include cytohesin-1 (B2-1), All GEFs have a highly conserved Sec7 domain, All cytohesins function in the cell periphery and contain a pleckstrin homology (PH) domain, Arf has a number of disparate activities including maintenance of organelle integrity, Arf is found to be active when bound to GTP and inactive when bound to GDP, Arf is involved in intracellular protein traffic to and within the Golgi complex, Arfâ, GEF activity lies in the Sec7 domain and this activity has been shown to be inhibited by the fungal metabolite brefeldin-A (BFA), Like other small GTPases, Recruitment of the cytohesins to the membranes can occur in response to tyrosine kinase receptor activation, The PH domain has been shown to interact with phosphatidylinositol 3, This response appears to require the activation of phosphatidylinositol 3-kinase (PI 3-kinase), and cytohesin-4, as a co-factor for cholera toxin and as an activator of phospholipase D, assembly of coat proteins, cytohesin-2 (ARNO), cytohesin-3 (ARNO3), which are members of the Ras superfamily of regulatory GTP-binding proteins, &euro, &trade, 4, 5-triphosphate and is believed to promote membrane targeting of the cytohesins, The ADP-ribosylation factor (Arf) family comprises a group of structurally and functionally conserved 21 kDa proteins, s activation is dependent upon guanine nucleotide exchange factors (GEFs) which increase the rate of exchange of bound GDP with GTP |
| Purification: |
Purified by Protein A |
| Storage conditions: |
50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission: |
553nm/568nm |
| Synonyms: |
CTS18, 1 Sec7p-L ARNO Sec7p-like cytohesin-2 CYTH2 |
| Properties: |
ALEXA FLUOR they should be stored frozen at - 24°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, Very high photo stable ALEXA conjugate, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
ALEXA FLUOR 555, Alexa Fluor |
| Gene target: |
Cytohesin 2 |
| Short name: |
Cytohesin 2 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Label: |
ALEXA FLUOR 555 |
| Alternative name: |
ALEXA FLUOR 555, Cytohesin 2 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
9503 |
| Gene: |
PSCD2L |
More about : PSCD2L |
| Long gene name: |
cytohesin 2 |
| Synonyms gene: |
PSCD2 |
| Synonyms gene name: |
Sec7 and coiled-coil domains 2 , Sec7 and coiled/coil domains 2 (cytohesin-2) pleckstrin homology, pleckstrin homology |
| Locus: |
19q13, 33 |
| Discovery year: |
1998-11-19 |
| GenBank acession: |
X99753 |
| Entrez gene record: |
9266 |
| Pubmed identfication: |
8706128 8945478 20525696 |
| RefSeq identity: |
NM_004228 |
| Classification: |
Pleckstrin homology domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000150245 |