| Long name: |
Cytohesin 2 Primary Polyclonal Antibody |
| Also known as: |
Cytohesin 2 PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
Cytohesin 2 |
| Specificity: |
This is a highly specific antibody against Cytohesin 2 |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Cytohesin 2 |
| Gene ID number: |
9266 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
A small group of GEFs which are insensitive to brefeldin-A (BFA) include cytohesin-1 (B2-1), All GEFs have a highly conserved Sec7 domain, All cytohesins function in the cell periphery and contain a pleckstrin homology (PH) domain, Arf has a number of disparate activities including maintenance of organelle integrity, Arf is found to be active when bound to GTP and inactive when bound to GDP, Arf is involved in intracellular protein traffic to and within the Golgi complex, Arfâ, GEF activity lies in the Sec7 domain and this activity has been shown to be inhibited by the fungal metabolite brefeldin-A (BFA), Like other small GTPases, Recruitment of the cytohesins to the membranes can occur in response to tyrosine kinase receptor activation, The PH domain has been shown to interact with phosphatidylinositol 3, This response appears to require the activation of phosphatidylinositol 3-kinase (PI 3-kinase), and cytohesin-4, as a co-factor for cholera toxin and as an activator of phospholipase D, assembly of coat proteins, cytohesin-2 (ARNO), cytohesin-3 (ARNO3), which are members of the Ras superfamily of regulatory GTP-binding proteins, &euro, &trade, 4, 5-triphosphate and is believed to promote membrane targeting of the cytohesins, The ADP-ribosylation factor (Arf) family comprises a group of structurally and functionally conserved 21 kDa proteins, s activation is dependent upon guanine nucleotide exchange factors (GEFs) which increase the rate of exchange of bound GDP with GTP |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
ARF nucleotide binding site opener, ARNO protein, Arno, CLM2, CTS18, CTS18, CYH2_HUMAN, Cyth2, Cytohesin 2, MGC137537, MGC80440, PH, PSCD2, PSCD2L, PSCD2L, Pleckstrin homology Sec7 and coiled coil domains 2, Pleckstrin homology Sec7 and coiled coil domains protein 2, SEC7 and coiled-coil domain-containing protein 2, SEC7 homolog B, SEC7L, Sec7, Sec7B, Sec7p L, Sec7p-like, Sec7pL, formerly, 1, ARF exchange factor |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
Cytohesin 2 |
| Short name: |
Cytohesin 2 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
Cytohesin 2 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
9503 |
| Gene: |
PSCD2L |
More about : PSCD2L |
| Long gene name: |
cytohesin 2 |
| Synonyms gene: |
PSCD2 |
| Synonyms gene name: |
Sec7 and coiled-coil domains 2 , Sec7 and coiled/coil domains 2 (cytohesin-2) pleckstrin homology, pleckstrin homology |
| Synonyms: |
CTS18, 1 Sec7p-L ARNO Sec7p-like cytohesin-2 CYTH2 |
| Locus: |
19q13, 33 |
| Discovery year: |
1998-11-19 |
| GenBank acession: |
X99753 |
| Entrez gene record: |
9266 |
| Pubmed identfication: |
8706128 8945478 20525696 |
| RefSeq identity: |
NM_004228 |
| Classification: |
Pleckstrin homology domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000150245 |