| Long name: |
Bile Acid Receptor NR1H4 Antibody |
| Also known as: |
Bile Acid Receptor NR1H4 Antibody |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
Bile Acid Receptor NR1H4 |
| Specificity: |
This is a highly specific antibody against Bile Acid Receptor NR1H4 |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
200-250/486 |
| Subcellular location: |
Nucleus |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Bile Acid Receptor NR1H4 |
| Gene ID number: |
9971 |
| Swiss Prot: |
Q96RI1 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Both LXR/RXR and FXR/RXR heterodimers retain their responsiveness to 9-cis retinoic acid, FXR and LXR fall into a category of proteins termed â, FXR has been shown to bind a class of lipid molecules called farnesoids, LXR/RXR heterodimers have highest affinity for DR-4 DNA elements while FXR/RXR heterodimers bind IR-1 elements, PPAR, RXR, TR, The promiscuous mediator of heterodimerization, and dimerizes with VDR, and in the case of LXR, and several novel receptors including LXR (also referred to as RLD-1) and FXR, is the receptor for 9-cis retinoic acid, the lack of a defined ligand, &euro, &euro, &oelig, The steroid receptor superfamily acts through direct association with DNA sequences known as hormone response elements (HREs) and binds DNA as either homo- or heterodimers, orphan receptorsâ, because of their lack of a defined function |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
Bile acid receptor, FXR, Farnesoid X-activated receptor, Farnesol receptor HRR-1, HRR-1, HRR1, NR1H4, Nuclear receptor subfamily 1 group H member 4, PFIC5, RIP14, RXR-interacting protein 14, Retinoid X receptor-interacting protein 14, BAR |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
Bile Acid Receptor NR1H4 |
| Short name: |
Bile Acid Receptor NR1H4 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
family H, member 4 (Antibody to), Bile Acid Receptor nuclear receptor subfamily 1 |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
BAR and FXR and HRR-1 and HRR1 and RIP14, BT, DNA-templated and biological process this GO :0006355 and regulation of transcription, DNA-templated and biological process this GO :0006357 and regulation of transcription from RNA polymerase II promoter and biological process this GO :0006367 and transcription initiation from RNA polymerase II promoter and biological process this GO :0007165 and signal transduction and biological process this GO :0008206 and bile acid metabolic process and biological process this GO :0008270 and zinc ion binding and molecular function this GO :0009749 and response to glucose and biological process this GO :0010467 and gene expression and biological process this GO :0016922 and ligand-dependent nuclear receptor binding and molecular function this GO :0030522 and intracellular receptor signaling pathway and biological process this GO :0032052 and bile acid binding and molecular function this GO :0032496 and response to lipopolysaccharide and biological process this GO :0034255 and regulation of urea metabolic process and biological process this GO :0038181 and bile acid receptor activity and molecular function this GO :0038185 and intracellular bile acid receptor signaling pathway and biological process this GO :0042277 and peptide binding and molecular function this GO :0043401 and steroid hormone mediated signaling pathway and biological process this GO :0043565 and sequence-specific DNA binding and molecular function this GO :0045087 and innate immune response and biological process this GO :0045944 and positive regulation of transcription from RNA polymerase II promoter and biological process this GO :0046965 and retinoid X receptor binding and molecular function this GO :0048565 and digestive tract development and biological process this GO :0070857 and regulation of bile acid biosynthetic process and biological process this GO :0070858 and negative regulation of bile acid biosynthetic process and biological process this GO :0071229 and cellular response to acid and biological process this GO :0071417 and cellular response to organonitrogen compound and biological process this GO :0090181 and regulation of cholesterol metabolic process and biological process this GO :1902122 and chenodeoxycholic acid binding and molecular function this GO :2000213 and positive regulation of glutamate metabolic process and biological process this GO :2001250 and positive regulation of ammonia assimilation cycle and biological process, NR1H4 and IDBG-52872 and ENSG00000012504 and 9971, Nr1h4 and IDBG-184281 and ENSMUSG00000047638 and 20186, chenodeoxycholic acid binding, group H, member 4, nuclei, this GO :0000122 and negative regulation of transcription from RNA polymerase II promoter and biological process this GO :0000978 and RNA polymerase II core promoter proximal region sequence-specific DNA binding and molecular function this GO :0000980 and RNA polymerase II distal enhancer sequence-specific DNA binding and molecular function this GO :0001077 and RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription and molecular function this GO :0001080 and nitrogen catabolite activation of transcription from RNA polymerase II promoter and biological process this GO :0001190 and RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription and molecular function this GO :0003677 and DNA binding and molecular function this GO :0003690 and double-stranded DNA binding and molecular function this GO :0003700 and sequence-specific DNA binding transcription factor activity and molecular function this GO :0003705 and RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity and molecular function this GO :0003707 and steroid hormone receptor activity and molecular function this GO :0003713 and transcription coactivator activity and molecular function this GO :0003714 and transcription corepressor activity and molecular function this GO :0004872 and receptor activity and molecular function this GO :0004879 and ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity and molecular function this GO :0004887 and thyroid hormone receptor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005654 and nucleoplasm and cellular component this GO :0005719 and nuclear euchromatin and cellular component this GO :0006109 and regulation of carbohydrate metabolic process and biological process this GO :0006351 and transcription, this GO :0000978 : RNA polymerase II core promoter proximal region sequence-specific DNA binding, this GO :0000978 : RNA polymerase II core promoter proximal region sequence-specific DNA binding and also this GO :0000980 : RNA polymerase II distal enhancer sequence-specific DNA binding and also this GO :0001077 : RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription and also this GO :0001190 : RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription and also this GO :0003677 : DNA binding and also this GO :0003690 : double-stranded DNA binding and also this GO :0003700 : sequence-specific DNA binding transcription factor activity and also this GO :0003705 : RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity and also this GO :0003707 : steroid hormone receptor activity and also this GO :0003713 : transcription coactivator activity and also this GO :0003714 : transcription corepressor activity and also this GO :0004872 : receptor activity and also this GO :0004879 : ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity and also this GO :0004887 : thyroid hormone receptor activity and also this GO :0005515 : protein binding and also this GO :0008270 : zinc ion binding and also this GO :0016922 : ligand-dependent nuclear receptor binding and also this GO :0032052 : bile acid binding and also this GO :0038181 : bile acid receptor activity and also this GO :0042277 : peptide binding and also this GO :0043565 : sequence-specific DNA binding and also this GO :0046965 : retinoid X receptor binding and also this GO :1902122 : chenodeoxycholic acid binding, this GO :0000980 : RNA polymerase II distal enhancer sequence-specific DNA binding, this GO :0001077 : RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription, this GO :0001190 : RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription, this GO :0003677 : DNA binding, this GO :0003690 : double-stranded DNA binding, this GO :0003700 : sequence-specific DNA binding transcription factor activity, this GO :0003705 : RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity, this GO :0003707 : steroid hormone receptor activity, this GO :0003713 : transcription coactivator activity, this GO :0003714 : transcription corepressor activity, this GO :0004872 : receptor activity, this GO :0004879 : ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity, this GO :0004887 : thyroid hormone receptor activity, this GO :0005515 : protein binding, this GO :0008270 : zinc ion binding, this GO :0016922 : ligand-dependent nuclear receptor binding, this GO :0032052 : bile acid binding, this GO :0038181 : bile acid receptor activity, this GO :0042277 : peptide binding, this GO :0043565 : sequence-specific DNA binding, this GO :0046965 : retinoid X receptor binding, this GO :1902122 : chenodeoxycholic acid binding, 48865 and IDBG-636894 and ENSBTAG00000013596 and 540528, nuclear receptor subfamily 1 |
| Identity: |
7967 |
| Gene: |
NR1H4 |
More about : NR1H4 |
| Long gene name: |
nuclear receptor subfamily 1 group H member 4 |
| Synonyms gene name: |
group H, member 4 , nuclear receptor subfamily 1 |
| Synonyms: |
FXR RIP14 HRR1 HRR-1 |
| Synonyms name: |
farnesoid X receptor |
| Locus: |
12q23, 1 |
| Discovery year: |
1999-09-17 |
| GenBank acession: |
U68233 |
| Entrez gene record: |
9971 |
| Pubmed identfication: |
7774010 9223286 |
| RefSeq identity: |
NM_005123 |
| Classification: |
Nuclear hormone receptors |
| Havana BLAST/BLAT: |
OTTHUMG00000170359 |