| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
FXR/Bile Acid Receptor NR1H4 |
| Specificity: |
This antibody reacts specifically with FXR/Bile Acid Receptor NR1H4 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human FXR/Bile Acid Receptor NR1H4 |
| Gene ID: |
9971 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Both LXR/RXR and FXR/RXR heterodimers retain their responsiveness to 9-cis retinoic acid, FXR and LXR fall into a category of proteins termed â, FXR has been shown to bind a class of lipid molecules called farnesoids, LXR/RXR heterodimers have highest affinity for DR-4 DNA elements while FXR/RXR heterodimers bind IR-1 elements, PPAR, RXR, TR, The promiscuous mediator of heterodimerization, and dimerizes with VDR, and in the case of LXR, and several novel receptors including LXR (also referred to as RLD-1) and FXR, is the receptor for 9-cis retinoic acid, the lack of a defined ligand, &euro, &euro, &oelig, The steroid receptor superfamily acts through direct association with DNA sequences known as hormone response elements (HREs) and binds DNA as either homo- or heterodimers, orphan receptorsâ, because of their lack of a defined function |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
FXR RIP14 HRR1 HRR-1 |
| Also known as: |
FXR/Bile Acid Receptor NR1H4 Antibody |
| Other name: |
Anti-FXR/Bile Acid Receptor NR1H4 |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Gene target: |
FXR/Bile Acid Receptor NR1H4 |
| Short name: |
Fluor 594, Anti-FXR/Bile Acid Receptor NR1H4 |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, family H, member 4, antibody to-FXR/Bile Acid Receptor nuclear receptor subfamily 1 |
| Alternative to gene target: |
BAR and FXR and HRR-1 and HRR1 and RIP14, BT, DNA-templated and biological process this GO :0006355 and regulation of transcription, DNA-templated and biological process this GO :0006357 and regulation of transcription from RNA polymerase II promoter and biological process this GO :0006367 and transcription initiation from RNA polymerase II promoter and biological process this GO :0007165 and signal transduction and biological process this GO :0008206 and bile acid metabolic process and biological process this GO :0008270 and zinc ion binding and molecular function this GO :0009749 and response to glucose and biological process this GO :0010467 and gene expression and biological process this GO :0016922 and ligand-dependent nuclear receptor binding and molecular function this GO :0030522 and intracellular receptor signaling pathway and biological process this GO :0032052 and bile acid binding and molecular function this GO :0032496 and response to lipopolysaccharide and biological process this GO :0034255 and regulation of urea metabolic process and biological process this GO :0038181 and bile acid receptor activity and molecular function this GO :0038185 and intracellular bile acid receptor signaling pathway and biological process this GO :0042277 and peptide binding and molecular function this GO :0043401 and steroid hormone mediated signaling pathway and biological process this GO :0043565 and sequence-specific DNA binding and molecular function this GO :0045087 and innate immune response and biological process this GO :0045944 and positive regulation of transcription from RNA polymerase II promoter and biological process this GO :0046965 and retinoid X receptor binding and molecular function this GO :0048565 and digestive tract development and biological process this GO :0070857 and regulation of bile acid biosynthetic process and biological process this GO :0070858 and negative regulation of bile acid biosynthetic process and biological process this GO :0071229 and cellular response to acid and biological process this GO :0071417 and cellular response to organonitrogen compound and biological process this GO :0090181 and regulation of cholesterol metabolic process and biological process this GO :1902122 and chenodeoxycholic acid binding and molecular function this GO :2000213 and positive regulation of glutamate metabolic process and biological process this GO :2001250 and positive regulation of ammonia assimilation cycle and biological process, NR1H4 and IDBG-52872 and ENSG00000012504 and 9971, Nr1h4 and IDBG-184281 and ENSMUSG00000047638 and 20186, chenodeoxycholic acid binding, group H, member 4, nuclei, this GO :0000122 and negative regulation of transcription from RNA polymerase II promoter and biological process this GO :0000978 and RNA polymerase II core promoter proximal region sequence-specific DNA binding and molecular function this GO :0000980 and RNA polymerase II distal enhancer sequence-specific DNA binding and molecular function this GO :0001077 and RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription and molecular function this GO :0001080 and nitrogen catabolite activation of transcription from RNA polymerase II promoter and biological process this GO :0001190 and RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription and molecular function this GO :0003677 and DNA binding and molecular function this GO :0003690 and double-stranded DNA binding and molecular function this GO :0003700 and sequence-specific DNA binding transcription factor activity and molecular function this GO :0003705 and RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity and molecular function this GO :0003707 and steroid hormone receptor activity and molecular function this GO :0003713 and transcription coactivator activity and molecular function this GO :0003714 and transcription corepressor activity and molecular function this GO :0004872 and receptor activity and molecular function this GO :0004879 and ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity and molecular function this GO :0004887 and thyroid hormone receptor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005654 and nucleoplasm and cellular component this GO :0005719 and nuclear euchromatin and cellular component this GO :0006109 and regulation of carbohydrate metabolic process and biological process this GO :0006351 and transcription, this GO :0000978 : RNA polymerase II core promoter proximal region sequence-specific DNA binding, this GO :0000978 : RNA polymerase II core promoter proximal region sequence-specific DNA binding and also this GO :0000980 : RNA polymerase II distal enhancer sequence-specific DNA binding and also this GO :0001077 : RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription and also this GO :0001190 : RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription and also this GO :0003677 : DNA binding and also this GO :0003690 : double-stranded DNA binding and also this GO :0003700 : sequence-specific DNA binding transcription factor activity and also this GO :0003705 : RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity and also this GO :0003707 : steroid hormone receptor activity and also this GO :0003713 : transcription coactivator activity and also this GO :0003714 : transcription corepressor activity and also this GO :0004872 : receptor activity and also this GO :0004879 : ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity and also this GO :0004887 : thyroid hormone receptor activity and also this GO :0005515 : protein binding and also this GO :0008270 : zinc ion binding and also this GO :0016922 : ligand-dependent nuclear receptor binding and also this GO :0032052 : bile acid binding and also this GO :0038181 : bile acid receptor activity and also this GO :0042277 : peptide binding and also this GO :0043565 : sequence-specific DNA binding and also this GO :0046965 : retinoid X receptor binding and also this GO :1902122 : chenodeoxycholic acid binding, this GO :0000980 : RNA polymerase II distal enhancer sequence-specific DNA binding, this GO :0001077 : RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription, this GO :0001190 : RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription, this GO :0003677 : DNA binding, this GO :0003690 : double-stranded DNA binding, this GO :0003700 : sequence-specific DNA binding transcription factor activity, this GO :0003705 : RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity, this GO :0003707 : steroid hormone receptor activity, this GO :0003713 : transcription coactivator activity, this GO :0003714 : transcription corepressor activity, this GO :0004872 : receptor activity, this GO :0004879 : ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity, this GO :0004887 : thyroid hormone receptor activity, this GO :0005515 : protein binding, this GO :0008270 : zinc ion binding, this GO :0016922 : ligand-dependent nuclear receptor binding, this GO :0032052 : bile acid binding, this GO :0038181 : bile acid receptor activity, this GO :0042277 : peptide binding, this GO :0043565 : sequence-specific DNA binding, this GO :0046965 : retinoid X receptor binding, this GO :1902122 : chenodeoxycholic acid binding, 48865 and IDBG-636894 and ENSBTAG00000013596 and 540528, nuclear receptor subfamily 1 |
| Identity: |
7967 |
| Gene: |
NR1H4 |
More about : NR1H4 |
| Long gene name: |
nuclear receptor subfamily 1 group H member 4 |
| Synonyms gene name: |
group H, member 4 , nuclear receptor subfamily 1 |
| Synonyms name: |
farnesoid X receptor |
| Locus: |
12q23, 1 |
| Discovery year: |
1999-09-17 |
| GenBank acession: |
U68233 |
| Entrez gene record: |
9971 |
| Pubmed identfication: |
7774010 9223286 |
| RefSeq identity: |
NM_005123 |
| Classification: |
Nuclear hormone receptors |
| Havana BLAST/BLAT: |
OTTHUMG00000170359 |