| Long name: |
Biotin Conjugated, PRAM1 Polyclonal Antibody |
| Category: |
Conjugated Primary Antibodies |
| Conjugation: |
Biotinylated |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
PRAM1 |
| Specificity: |
This is a highly specific antibody against PRAM1 |
| Modification: |
Unmodified |
| Modification site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
KLH conjugated synthetic peptide derived from human PRAM1 |
| Tested applications: |
IHC-P, WB |
| Recommended dilutions: |
IHC-P(1:100-500), WB(1:100-1000) |
| Crossreactivity: |
Mouse, Rat, Human |
| Crossreactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background: |
PRAM-1 (PML-RAR-a target gene encoding an adaptor molecule 1) encodes an adaptor protein which is expressed and modulated during normal human myelopoiesis, PRAM-1 demonstrates expression in hematopoietic tissues and lung, PRAM-1 expression is hindered by expression of PML-RAR-a, The 718 amino acid PRAM-1 protein contains eight N-terminal proline-rich repeats and several proline residues that are clustered as type I or type II SH3 recognition motifs, The retinoic acid-induced gene, and PML-RAR-a (promyelocytic leukemia-retinoic acid receptor alpha fusion protein) plays a major role in mediating retinoic acid effects in leukemia cells, Complete remission of acute promyelocytic leukemia can be achieved by treating patients with retinoic acid |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Synonyms: |
PML-RAR |
| Properties: |
Avidin and Streptavidin bind to the small biotin and are couple to HRP or AP for ELISA, Biotin conjugates can be detected by horseradish peroxidase, To break the streptavidin Biotin bond we suggest to use a 6 molar guanidine HCl solution with acidity of pH 1, alkaline phosphatase substrates or anti biotin conjugated antibodies, 6, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
PRAM1 Conjugated |
| Short name: |
Conjugated, PRAM1 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label: |
Biotin |
| Alternative name: |
alpha regulated adaptor molecule 1 (Antibody to), biotinilated coupled, promyelocytic leukemia-retinoic acid receptor |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
PRAM1 and IDBG-24943 and ENSG00000133246 and 84106, PRAM1 and IDBG-643837 and ENSBTAG00000021041 and 504848, Pram1 and IDBG-167526 and ENSMUSG00000032739 and 378460, lipid binding, multiple, this GO :0005515 and protein binding and molecular function this GO :0007229 and integrin-mediated signaling pathway and biological process this GO :0008289 and lipid binding and molecular function this GO :0043313 and regulation of neutrophil degranulation and biological process, this GO :0005515 : protein binding, this GO :0005515 : protein binding and also this GO :0008289 : lipid binding, this GO :0008289 : lipid binding, PML-RARA regulated adaptor molecule 1 |
| Identity: |
30091 |
| Gene: |
PRAM1 |
More about : PRAM1 |
| Long gene name: |
PML-RARA regulated adaptor molecule 1 |
| Locus: |
19p13, 2 |
| Discovery year: |
2005-07-04 |
| GenBank acession: |
BC028012 |
| Entrez gene record: |
84106 |
| Pubmed identfication: |
11301322 15572693 |
| RefSeq identity: |
NM_032152 |
| Havana BLAST/BLAT: |
OTTHUMG00000167924 |