ATF2 (Thr51 + Thr53) Antibody, Biotin Conjugated

Catalog number:	bs-12537R-Biotin Buy Now
Price:	368 €
Supplier:	Bioss Primary Conjugated Antibodies
Product name:	ATF2 (Thr51 + Thr53) Antibody, Biotin Conjugated
Quantity:	0.1ml
Related search:	atf thr antibody antibodies biotin gene factor neurotrophic kinase

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Long name:	Biotin Conjugated, ATF2 (Thr51 + Thr53) Polyclonal Antibody
Category:	Conjugated Primary Antibodies
Conjugation:	Biotinylated
Host Organism:	Rabbit (Oryctolagus cuniculus)
Target Antigen:	ATF2 Thr51 + Thr53
Specificity:	This is a highly specific antibody against ATF2 Thr51 + Thr53
Modification:	Phosphorylation
Modification site:	Thr51 + Thr53
Clonality:	Polyclonal
Clone:	Polyclonal antibody
Concentration:	1ug per 1ul
Source:	KLH conjugated synthetic phosphopeptide derived from mouse ATF2 around the phosphorylation site of Thr51 + Thr53
Gene ID number:	11909
Tested applications:	IHC-P, WB
Recommended dilutions:	IHC-P(1:100-500), WB(1:100-1000)
Crossreactivity:	Mouse, Rat, Human
Crossreactive species details:	not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Antigen background:	ATF2 is a nuclear protein that binds DNA as a dimer and can form dimers with members of the ATF/CREB and Jun/Fos families, ATF2 is abundantly expressed in brain, Following dimerization ATF2 becomes a short lived protein that undergoes ubiquitination and proteolysis, It is a stronger activator as a heterodimer with cJun than as a homodimer, Many of these genes are important in cell growth and differentiation, Several isoforms of ATF2 arise by differential splicing, Stimulation of the transcriptional activity of ATF2 occurs following cellular stress induced by several genotoxic agents, The stable native full length ATF2 is transcriptionally inactive as a result of an inhibitory direct intramolecular interaction of its carboxy terminal DNA binding domain with the amino terminal transactivation domain, This activation requires phosphorylation of two threonine residues in ATF2 by both JNK/SAP kinase and p38 MAP kinase, and UV irradiation, and in stress and immune responses, inflammatory cytokines, seemingly in a protein phosphatase-dependent mechanism, ATF2 is a member of the ATF/CREB family of basic region leucine zipper DNA binding proteins that regulates transcription by binding to a consensus cAMP response element (CRE) in the promoter of various viral and cellular genes
Purification method:	This antibody was purified via Protein A
Storage conditions:	50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA
Synonyms:	ATF1 ATF2 HFB1-GDNF
Properties:	Avidin and Streptavidin bind to the small biotin and are couple to HRP or AP for ELISA, Biotin conjugates can be detected by horseradish peroxidase, To break the streptavidin Biotin bond we suggest to use a 6 molar guanidine HCl solution with acidity of pH 1, alkaline phosphatase substrates or anti biotin conjugated antibodies, 6, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°
Gene target:	ATF2 (Thr51 + Thr53) Conjugated
Short name:	Conjugated, ATF2 (Thr51 + Thr53) Antibody
Technique:	antibodies against human proteins, antibodies for, antibody Conjugates, Antibody
Label:	Biotin
Alternative name:	biotinilated coupled, ATF2 (Thr51 and Thr53) (Antibody to)
Alternative technique:	antibodies
Identity:	4232
Gene:	GDNF | More about : GDNF
Long gene name:	glial cell derived neurotrophic factor
Synonyms name:	astrocyte-derived trophic factor glial cell line derived neurotrophic factor glial derived neurotrophic factor
Locus:	5p13, 2
Discovery year:	1995-05-04
Entrez gene record:	2668
Pubmed identfication:	8493557
RefSeq identity:	NM_000514
Classification:	Endogenous ligands
Havana BLAST/BLAT:	OTTHUMG00000090809

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