ATF2 (Ser480) Antibody, ALEXA FLUOR 350

Catalog number:	bs-12536R-A350 Buy Now
Price:	350 €
Supplier:	Bioss Primary Conjugated Antibodies.
Product name:	ATF2 (Ser480) Antibody, ALEXA FLUOR 350
Quantity:	100ul
Related search:	atf alexa ser fluor antibody antibodies gene factor neurotrophic kinase

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Long name:	ALEXA FLUOR 350 Conjugated, ATF2 (Ser480) Polyclonal Antibody
Also known as:	Anti-ATF2 Ser480 PAb ALEXA FLUOR 350
Category:	Conjugated Primary Antibodies
Conjugated with:	350, ALEXA FLUOR®
Host Organism:	Rabbit (Oryctolagus cuniculus)
Target Antigen:	ATF2 Ser480
Specificity:	This is a highly specific antibody against ATF2 Ser480
Modification:	Phosphorylation
Modification Site:	Ser480
Clonality:	Polyclonal
Clone:	Polyclonal antibody
Concentration:	1ug per 1ul
Source:	KLH conjugated synthetic phosphopeptide derived from mouse ATF2 around the phosphorylation site of Ser480
Gene ID Number:	11909
Tested applications:	IF(IHC-P)
Recommended dilutions:	IF(IHC-P)(1:50-200)
Crossreactivity:	Mouse, Human
Cross-reactive species details:	not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the antigen:	ATF2 is a nuclear protein that binds DNA as a dimer and can form dimers with members of the ATF/CREB and Jun/Fos families, ATF2 is abundantly expressed in brain, Following dimerization ATF2 becomes a short lived protein that undergoes ubiquitination and proteolysis, It is a stronger activator as a heterodimer with cJun than as a homodimer, Many of these genes are important in cell growth and differentiation, Several isoforms of ATF2 arise by differential splicing, Stimulation of the transcriptional activity of ATF2 occurs following cellular stress induced by several genotoxic agents, The stable native full length ATF2 is transcriptionally inactive as a result of an inhibitory direct intramolecular interaction of its carboxy terminal DNA binding domain with the amino terminal transactivation domain, This activation requires phosphorylation of two threonine residues in ATF2 by both JNK/SAP kinase and p38 MAP kinase, and UV irradiation, and in stress and immune responses, inflammatory cytokines, seemingly in a protein phosphatase-dependent mechanism, ATF2 is a member of the ATF/CREB family of basic region leucine zipper DNA binding proteins that regulates transcription by binding to a consensus cAMP response element (CRE) in the promoter of various viral and cellular genes
Purification:	Purified by Protein A
Storage conditions:	50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA
Excitation emission:	343nm/442nm
Synonyms:	ATF1 ATF2 HFB1-GDNF
Properties:	ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 350 conjugates can be used in multi-color flow cytometry with FACS's equipped with a second red laser or red diode, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate
Conjugation:	ALEXA FLUOR 350, Alexa Fluor
Gene target:	ATF2 (Ser480)
Short name:	ATF2 (Ser480) Antibody
Technique:	antibodies against human proteins, antibodies for, Antibody
Label:	ALEXA FLUOR 350
Alternative name:	ALEXA FLUOR 350, ATF2 (Ser480) (Antibody to)
Alternative technique:	antibodies
Identity:	4232
Gene:	GDNF | More about : GDNF
Long gene name:	glial cell derived neurotrophic factor
Synonyms name:	astrocyte-derived trophic factor glial cell line derived neurotrophic factor glial derived neurotrophic factor
Locus:	5p13, 2
Discovery year:	1995-05-04
Entrez gene record:	2668
Pubmed identfication:	8493557
RefSeq identity:	NM_000514
Classification:	Endogenous ligands
Havana BLAST/BLAT:	OTTHUMG00000090809

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