| Long name: |
ALEXA FLUOR 647 Conjugated, FRAT2 Polyclonal Antibody |
| Also known as: |
Anti-FRAT2 PAb ALEXA FLUOR 647 |
| Category: |
Conjugated Primary Antibodies |
| Conjugated with: |
647, ALEXA FLUOR® |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
FRAT2 |
| Specificity: |
This is a highly specific antibody against FRAT2 |
| Modification: |
Unmodified |
| Modification Site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human FRAT2 |
| Gene ID Number: |
23401 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Cross-reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen: |
Establishment of these embryonic axes is mediated by the Wnt intracellular signaling pathway, FRAT2 has been shown to bind xGSK-3, GBP binds to GSK-3 and inhibits this phosphorylation, Like GBP, These proteins share significant homology with the Xenopus glycogen synthase kinase-3 (xGSK-3) binding protein, Wnt signaling is regulated in part by the activity of GSK-3, and they have since been identified as proto-oncogenes involved in tumorigenesis, resulting in the accumulation of ?catenin and the subsequent transcription of Wnt target genes, suggesting that FRAT1 and FRAT2 may be GSK-3 regulatory proteins, which is designated GBP and is essential for the formation of the dorsal-ventral axis during embryonic development, which phosphorylates and thereby facilitates the degradation of ?catenin, FRAT1 and FRAT2 were originally characterized as proteins frequently rearranged in advanced T cell lymphoma |
| Purification: |
Purified by Protein A |
| Storage conditions: |
50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission: |
650nm/665nm |
| Properties: |
ALEXA FLUOR made this Alexa Fluor 633 conjugate that can be used in multi-color flow cytometry with instruments equipped with a second red laser or red diode, ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 633 is a practical alternative to APC as well as Cy5, Bioss Primary Conjugated Antibodies, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, It is detected in the FL4 detector of the core's upgraded 2-laser FACScans, Like other Alexa Fluor dyes, exhibits uncommon photo stability, making it an ideal choice for fluorescent microscopy, the FRAT2 Antibody, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
ALEXA FLUOR 647, Alexa Fluor |
| Gene target: |
FRAT2 |
| Short name: |
FRAT2 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Label: |
ALEXA FLUOR 647 |
| Alternative name: |
ALEXA FLUOR 647, frequently rearranged in advanced T-cellular lymphomas 2 (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
FRAT2 and IDBG-648820 and ENSBTAG00000046701 and 539144, FRAT2 and IDBG-84538 and ENSG00000181274 and 23401, Frat2 and IDBG-166307 and ENSMUSG00000047604 and 212398, molecular_function, multiple, this GO :0003674 and molecular function and molecular function this GO :0005575 and cellular component and cellular component this GO :0007275 and multicellular organismal development and biological process this GO :0008283 and cell proliferation and biological process this GO :0016055 and Wnt signaling pathway and biological process, this GO :0003674 : molecular_function, this GO :0003674 : molecular_function, frequently rearranged in advanced T-cell lymphomas 2 |
| Identity: |
16048 |
| Gene: |
FRAT2 |
More about : FRAT2 |
| Long gene name: |
FRAT2, WNT signaling pathway regulator |
| Synonyms gene name: |
frequently rearranged in advanced T-cell lymphomas 2 |
| Synonyms name: |
GSK-3 binding protein FRAT2 |
| Locus: |
10q24, 1 |
| Discovery year: |
2001-07-06 |
| GenBank acession: |
AF062739 |
| Entrez gene record: |
23401 |
| Pubmed identfication: |
9635432 11237732 |
| RefSeq identity: |
NM_012083 |
| Havana BLAST/BLAT: |
OTTHUMG00000018850 |