| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
FRAT2 |
| Specificity: |
This antibody reacts specifically with FRAT2 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human FRAT2 |
| Gene ID: |
23401 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Establishment of these embryonic axes is mediated by the Wnt intracellular signaling pathway, FRAT2 has been shown to bind xGSK-3, GBP binds to GSK-3 and inhibits this phosphorylation, Like GBP, These proteins share significant homology with the Xenopus glycogen synthase kinase-3 (xGSK-3) binding protein, Wnt signaling is regulated in part by the activity of GSK-3, and they have since been identified as proto-oncogenes involved in tumorigenesis, resulting in the accumulation of ?catenin and the subsequent transcription of Wnt target genes, suggesting that FRAT1 and FRAT2 may be GSK-3 regulatory proteins, which is designated GBP and is essential for the formation of the dorsal-ventral axis during embryonic development, which phosphorylates and thereby facilitates the degradation of ?catenin, FRAT1 and FRAT2 were originally characterized as proteins frequently rearranged in advanced T cell lymphoma |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Also known as: |
FRAT2 Polyclonal Antibody |
| Other name: |
Anti-FRAT2 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
FRAT2 |
| Short name: |
Anti-FRAT2 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-frequently rearranged in advanced T-cellular lymphomas 2 (polyclonal) |
| Alternative technique: |
polyclonals |
| Alternative to gene target: |
FRAT2 and IDBG-648820 and ENSBTAG00000046701 and 539144, FRAT2 and IDBG-84538 and ENSG00000181274 and 23401, Frat2 and IDBG-166307 and ENSMUSG00000047604 and 212398, molecular_function, multiple, this GO :0003674 and molecular function and molecular function this GO :0005575 and cellular component and cellular component this GO :0007275 and multicellular organismal development and biological process this GO :0008283 and cell proliferation and biological process this GO :0016055 and Wnt signaling pathway and biological process, this GO :0003674 : molecular_function, this GO :0003674 : molecular_function, frequently rearranged in advanced T-cell lymphomas 2 |
| Identity: |
16048 |
| Gene: |
FRAT2 |
More about : FRAT2 |
| Long gene name: |
FRAT2, WNT signaling pathway regulator |
| Synonyms gene name: |
frequently rearranged in advanced T-cell lymphomas 2 |
| Synonyms name: |
GSK-3 binding protein FRAT2 |
| Locus: |
10q24, 1 |
| Discovery year: |
2001-07-06 |
| GenBank acession: |
AF062739 |
| Entrez gene record: |
23401 |
| Pubmed identfication: |
9635432 11237732 |
| RefSeq identity: |
NM_012083 |
| Havana BLAST/BLAT: |
OTTHUMG00000018850 |