| Long name: |
Cy3 Conjugated, MELK/HPK38 Polyclonal Antibody |
| Category: |
Conjugated Primary Antibodies |
| Conjugation: |
cy3 conjugation kit |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
MELK/HPK38 |
| Specificity: |
This is a highly specific antibody against MELK/HPK38 |
| Modification: |
Unmodified |
| Modification site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen_range: |
130-180/651 |
| Subcellular location: |
Cell membrane |
| Source: |
KLH conjugated synthetic peptide derived from human MELK/HPK38 |
| Gene ID number: |
9833 |
| Swiss Prot: |
Q14680 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Crossreactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background: |
Acts as a regulator of cell cycle, Acts as an activator of apoptosis by phosphorylating and activating MAP3K5/ASK1, Also involved in the inhibition of spliceosome assembly during mitosis by phosphorylating ZNF622, CDC25B, Has a broad substrate specificity, MAP3K5/ASK1 and ZNF622, May also play a role in primitive hematopoiesis, Phosphorylates and inhibits BCL2L14, Plays a key role in cell proliferation and carcinogenesis, Required for proliferation of embryonic and postnatal multipotent neural progenitors, apoptosis and splicing regulation, notably by mediating phosphorylation of CDC25B, phosphorylates BCL2L14, possibly leading to affect mammary carcinogenesis by mediating inhibition of the pro-apoptotic function of BCL2L14, promoting localization of CDC25B to the centrosome and the spindle poles during mitosis, self-renewal of stem cells, thereby contributing to its redirection to the nucleus, Serine/threonine-protein kinase involved in various processes such as cell cycle regulation |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Excitation Emission: |
512, 550nm/570, 615nm |
| Synonyms: |
KIAA0175 |
| Properties: |
1 of the MELK/HPK38 Antibody, Conjugated can be used in flow cytometry but typically shows lower fluorescence intensity comparable to that of PE or APC, Cy3 antibodies are excited by the 488-nanometer wave of an argon laser and the 633-nanometer line of a helium-neon diode laser, This Bioss Primary Conjugated Antibodies antibody is well suited for fluorescent microscopy, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
MELK/HPK38 Conjugated |
| Short name: |
Conjugated, MELK/HPK38 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label: |
Cy3 |
| Alternative name: |
cyanine 3 coupled, MELK/HPK38 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
16870 |
| Gene: |
MELK |
More about : MELK |
| Long gene name: |
maternal embryonic leucine zipper kinase |
| Locus: |
9p13, 2 |
| Discovery year: |
2003-02-04 |
| GenBank acession: |
D79997 |
| Entrez gene record: |
9833 |
| Pubmed identfication: |
8724849 9136115 |
| RefSeq identity: |
NM_014791 |
| Havana BLAST/BLAT: |
OTTHUMG00000019906 |