| Long name: |
Cy5, 5 Conjugated, ROCK2 Polyclonal Antibody |
| Category: |
Conjugated Primary Antibodies |
| Conjugation: |
Cy5, 5, 5, Cy5 |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
ROCK2 |
| Specificity: |
This is a highly specific antibody against ROCK2 |
| Modification: |
Unmodified |
| Modification site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen_range: |
1035-1085/1388 |
| Subcellular location: |
Cytoplasm |
| Source: |
KLH conjugated synthetic peptide derived from human ROCK2 |
| Gene ID number: |
9475 |
| Swiss Prot: |
O75116 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Crossreactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background: |
Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation, BRCA2, CNN1, DPYSL2, EP3, EZR, Inhibits keratinocyte terminal differentiation, Involved in regulation of smooth muscle contraction, MSN, MYL9/MLC2, May regulate closure of the eyelids and ventral body wall through organization of actomyosin bundles, NPM1, PPP1R12A and VIM, Phosphorylates SORL1 and IRF4, Plays a critical role in the regulation of spine and synaptic properties in the hippocampus, Plays an important role in generating the circadian rhythm of the aortic myofilament Ca(2+) sensitivity and vascular contractility by modulating the myosin light chain phosphorylation, Plays an important role in the timely initiation of centrosome duplication, Positively regulates the activation of p42/MAPK1-p44/MAPK3 and of p9RSK/RPS6KA1 during myogenic differentiation, RDX, actin cytoskeleton organization, cell adhesion and motility via phosphorylation of ADD1, neurite retraction, stress fiber and focal adhesion formation, Protein kinase which is a key regulator of actin cytoskeleton and cell polarity |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Excitation Emission: |
675nm/694nm |
| Properties: |
Cy5 antibodies are excited by the 650-nanometer wave of an argon laser and detected at a 670-nanometer captor, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24° |
| Conjugated: |
These antibodies are excite for emission at 678nm and detected at a 694 , nm wavelengths |
| Gene target: |
ROCK2 Conjugated |
| Short name: |
Conjugated, ROCK2 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label: |
5, Cy5 |
| Alternative name: |
coiled-coil containing protein kinase 2 (Antibody to), cyanine 5, 5 coupled, Rho-associated |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
ROCK-II, ROCK2 and IDBG-29657 and ENSG00000134318 and 9475, ROCK2 and IDBG-638012 and ENSBTAG00000005847 and 282041, Rock2 and IDBG-129486 and ENSMUSG00000020580 and 19878, coiled-coil containing protein kinase 2, nuclei, this GO :0000166 and nucleotide binding and molecular function this GO :0000910 and cytokinesis and biological process this GO :0001843 and neural tube closure and biological process this GO :0004672 and protein kinase activity and molecular function this GO :0004674 and protein serine/threonine kinase activity and molecular function this GO :0004713 and protein tyrosine kinase activity and molecular function this GO :0005198 and structural molecule activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005524 and ATP binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005813 and centrosome and cellular component this GO :0005829 and cytosol and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0006468 and protein phosphorylation and biological process this GO :0006939 and smooth muscle contraction and biological process this GO :0007411 and axon guidance and biological process this GO :0008625 and extrinsic apoptotic signaling pathway via death domain receptors and biological process this GO :0010825 and positive regulation of centrosome duplication and biological process this GO :0016525 and negative regulation of angiogenesis and biological process this GO :0016772 and transferase activity, this GO :0000166 : nucleotide binding, this GO :0000166 : nucleotide binding and also this GO :0004672 : protein kinase activity and also this GO :0004674 : protein serine/threonine kinase activity and also this GO :0004713 : protein tyrosine kinase activity and also this GO :0005198 : structural molecule activity and also this GO :0005515 : protein binding and also this GO :0005524 : ATP binding and also this GO :0016772 : transferase activity, this GO :0004672 : protein kinase activity, this GO :0004674 : protein serine/threonine kinase activity, this GO :0004713 : protein tyrosine kinase activity, this GO :0005198 : structural molecule activity, this GO :0005515 : protein binding, this GO :0005524 : ATP binding, this GO :0016772 : transferase activity, this GO :0017048 : Rho GTPase binding, this GO :0044822 : poly(A) RNA binding, this GO :0046872 : metal ion binding, transferase activity, transferring phosphorus-containing groups, transferring phosphorus-containing groups and also this GO :0017048 : Rho GTPase binding and also this GO :0044822 : poly(A) RNA binding and also this GO :0046872 : metal ion binding, transferring phosphorus-containing groups and molecular function this GO :0017048 and Rho GTPase binding and molecular function this GO :0030036 and actin cytoskeleton organization and biological process this GO :0030155 and regulation of cell adhesion and biological process this GO :0031616 and spindle pole centrosome and cellular component this GO :0032956 and regulation of actin cytoskeleton organization and biological process this GO :0035556 and intracellular signal transduction and biological process this GO :0036464 and cytoplasmic ribonucleoprotein granule and cellular component this GO :0042752 and regulation of circadian rhythm and biological process this GO :0044822 and poly(A) RNA binding and molecular function this GO :0045616 and regulation of keratinocyte differentiation and biological process this GO :0046872 and metal ion binding and molecular function this GO :0048511 and rhythmic process and biological process this GO :0051298 and centrosome duplication and biological process this GO :0051492 and regulation of stress fiber assembly and biological process this GO :0051893 and regulation of focal adhesion assembly and biological process this GO :2000114 and regulation of establishment of cell polarity and biological process this GO :2000145 and regulation of cell motility and biological process, Rho-associated |
| Identity: |
10252 |
| Gene: |
ROCK2 |
More about : ROCK2 |
| Long gene name: |
Rho associated coiled-coil containing protein kinase 2 |
| Locus: |
2p25, 1 |
| Discovery year: |
1999-04-23 |
| GenBank acession: |
D87931 |
| Entrez gene record: |
9475 |
| Pubmed identfication: |
9933571 |
| Classification: |
Pleckstrin homology domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000149916 |