| Long name: |
CAPON Primary Polyclonal Antibody |
| Also known as: |
CAPON PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
CAPON |
| Specificity: |
This is a highly specific antibody against CAPON |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human CAPON |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Biosynthesis of the neurotransmitter nitric oxide (NO) requires the association of nNOS with various synaptic proteins, The association of nNOS with PSD95 or PSD93 is regulated by CAPON, The carboxy terminus of CAPON binds to the PDZ domain, These proteins facilitate the transport of nNOS to the plasma membrane, and sequesters nNOS in the cytosol, but not to endothelial NOS or inducible NOS, competes with PSD95 and PSD93 for binding to nNOS and in turn prevents the translocation and catalytic activation of nNOS, including syntrophin, postsynaptic density (PSD)95 and PSD93 through a scaffolding PDZ domain, where it is catalytically activated by NMDA-receptor mediated calcium channels, CAPON (carboxy-terminal PDZ ligand of nNOS) selectively binds within the 100 amino acid PDZ domain of the neuronal nitric oxide synthase (nNOS) |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
C terminal PDZ domain ligand of neuronal nitric oxide synthase, C terminal PDZ domain ligand of neuronal nitric oxide synthase CAPON, C terminal PDZ ligand of neuronal nitric oxide synthase protein, C-terminal PDZ ligand of neuronal nitric oxide synthase protein, CAPON, CAPON_HUMAN, Carboxyl terminal PDZ ligand of neuronal nitric oxide synthase protein, Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein, Ligand of neuronal nitric oxide synthase with carboxyl terminal PDZ domain, MGC138500, Nitric oxide synthase 1 adaptor protein, Nitric oxide synthase 1 neuronal adaptor protein, NOS1AP |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
CAPON |
| Short name: |
CAPON Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
CAPON (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
16859 |
| Gene: |
NOS1AP |
More about : NOS1AP |
| Long gene name: |
nitric oxide synthase 1 adaptor protein |
| Synonyms gene name: |
nitric oxide synthase 1 (neuronal) adaptor protein |
| Synonyms: |
KIAA0464 CAPON |
| Synonyms name: |
C-terminal PDZ domain ligand of neuronal nitric oxide synthase |
| Locus: |
1q23, 3 |
| Discovery year: |
2005-06-15 |
| GenBank acession: |
AB007933 |
| Entrez gene record: |
9722 |
| Pubmed identfication: |
9455484 9459447 |
| RefSeq identity: |
NM_014697 |
| Havana BLAST/BLAT: |
OTTHUMG00000024049 |