| Long name: |
NOTCH1/activated Notch1 Antibody |
| Also known as: |
NOTCH1/activated Notch1 Antibody |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
NOTCH1/activated Notch1 |
| Specificity: |
This is a highly specific antibody against NOTCH1/activated Notch1 |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Subcellular location: |
Extracellular |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human NOTCH1/activated Notch1 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Delta expression has also been found in neuroendocrine tumors such as neuroblastomas and pheochromocytomas, Jagged can activate notch and prevent myoblast differentiation by inhibiting the expression of muscle regulatory and structural genes, Jagged2 and Delta, Jagged2 is thought to be involved in the development of various tissues whose development is dependent upon epithelial-mesenchymal interactions, Ligands for notch include Jagged1, Normal Delta expression is restricted to the adrenal gland and placenta, Notch 2, Notch 3 and Notch 4, The notch genes are expressed in a variety of tissues in both the embryonic and adult organism, The notch proteins have been found to be overexpressed or rearranged in human tumors, To date, four notch homologs have been identified in mammals and have been designated Notch 1, suggesting that the genes are involved in multiple signaling pathways, The LIN-12/notch family of transmembrane receptors is believed to play a central role in development by regulating cell fate decisions |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
NOTCH1, Neurogenic locus Notch homolog protein 1, TAN1, Translocation-associated Notch protein TAN-1, activated Notch 1, activated Notch-1, Notch homolog 1 translocation associated Drosophila, hN1 |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
NOTCH1/activated Notch1 |
| Short name: |
NOTCH1/activated Notch1 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
notch 1/activated notch 1 (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
AOS5 and AOVD1 and hN1 and TAN1, DNA-templated and biological process this GO :0006357 and regulation of transcription from RNA polymerase II promoter and biological process this GO :0006367 and transcription initiation from RNA polymerase II promoter and biological process this GO :0006955 and immune response and biological process this GO :0006959 and humoral immune response and biological process this GO :0007219 and Notch signaling pathway and biological process this GO :0007220 and Notch receptor processing and biological process this GO :0007221 and positive regulation of transcription of Notch receptor target and biological process this GO :0007275 and multicellular organismal development and biological process this GO :0007283 and spermatogenesis and biological process this GO :0007368 and determination of left/right symmetry and biological process this GO :0007386 and compartment pattern specification and biological process this GO :0007409 and axonogenesis and biological process this GO :0007420 and brain development and biological process this GO :0007440 and foregut morphogenesis and biological process this GO :0007492 and endoderm development and biological process this GO :0007507 and heart development and biological process this GO :0008284 and positive regulation of cell proliferation and biological process this GO :0008285 and negative regulation of cell proliferation and biological process this GO :0008544 and epidermis development and biological process this GO :0009912 and auditory receptor cell fate commitment and biological process this GO :0009986 and cell surface and cellular component this GO :0010001 and glial cell differentiation and biological process this GO :0010467 and gene expression and biological process this GO :0010468 and regulation of gene expression and biological process this GO :0010718 and positive regulation of epithelial to mesenchymal transition and biological process this GO :0010812 and negative regulation of cell-substrate adhesion and biological process this GO :0010832 and negative regulation of myotube differentiation and biological process this GO :0014031 and mesenchymal cell development and biological process this GO :0014807 and regulation of somitogenesis and biological process this GO :0016020 and membrane and cellular component this GO :0016021 and integral component of membrane and cellular component this GO :0019899 and enzyme binding and molecular function this GO :0021515 and cell differentiation in spinal cord and biological process this GO :0021915 and neural tube development and biological process this GO :0030154 and cell differentiation and biological process this GO :0030182 and neuron differentiation and biological process this GO :0030216 and keratinocyte differentiation and biological process this GO :0030279 and negative regulation of ossification and biological process this GO :0030324 and lung development and biological process this GO :0030326 and embryonic limb morphogenesis and biological process this GO :0030334 and regulation of cell migration and biological process this GO :0030335 and positive regulation of cell migration and biological process this GO :0030513 and positive regulation of BMP signaling pathway and biological process this GO :0030514 and negative regulation of BMP signaling pathway and biological process this GO :0030900 and forebrain development and biological process this GO :0031069 and hair follicle morphogenesis and biological process this GO :0031100 and organ regeneration and biological process this GO :0031490 and chromatin DNA binding and molecular function this GO :0031960 and response to corticosteroid and biological process this GO :0032495 and response to muramyl dipeptide and biological process this GO :0032496 and response to lipopolysaccharide and biological process this GO :0035116 and embryonic hindlimb morphogenesis and biological process this GO :0035148 and tube formation and biological process this GO :0035914 and skeletal muscle cell differentiation and biological process this GO :0035924 and cellular response to vascular endothelial growth factor stimulus and biological process this GO :0042127 and regulation of cell proliferation and biological process this GO :0042246 and tissue regeneration and biological process this GO :0042640 and anagen and biological process this GO :0043065 and positive regulation of apoptotic process and biological process this GO :0043086 and negative regulation of catalytic activity and biological process this GO :0043235 and receptor complex and cellular component this GO :0043565 and sequence-specific DNA binding and molecular function this GO :0045087 and innate immune response and biological process this GO :0045165 and cell fate commitment and biological process this GO :0045596 and negative regulation of cell differentiation and biological process this GO :0045603 and positive regulation of endothelial cell differentiation and biological process this GO :0045618 and positive regulation of keratinocyte differentiation and biological process this GO :0045662 and negative regulation of myoblast differentiation and biological process this GO :0045665 and negative regulation of neuron differentiation and biological process this GO :0045668 and negative regulation of osteoblast differentiation and biological process this GO :0045687 and positive regulation of glial cell differentiation and biological process this GO :0045892 and negative regulation of transcription, DNA-templated and biological process this GO :0045893 and positive regulation of transcription, DNA-templated and biological process this GO :0045944 and positive regulation of transcription from RNA polymerase II promoter and biological process this GO :0045955 and negative regulation of calcium ion-dependent exocytosis and biological process this GO :0046427 and positive regulation of JAK-STAT cascade and biological process this GO :0046533 and negative regulation of photoreceptor cell differentiation and biological process this GO :0048103 and somatic stem cell division and biological process this GO :0048663 and neuron fate commitment and biological process this GO :0048708 and astrocyte differentiation and biological process this GO :0048709 and oli this GO dendrocyte differentiation and biological process this GO :0048711 and positive regulation of astrocyte differentiation and biological process this GO :0048715 and negative regulation of oli this GO dendrocyte differentiation and biological process this GO :0048754 and branching morphogenesis of an epithelial tube and biological process this GO :0050678 and regulation of epithelial cell proliferation and biological process this GO :0050679 and positive regulation of epithelial cell proliferation and biological process this GO :0050767 and regulation of neurogenesis and biological process this GO :0050768 and negative regulation of neurogenesis and biological process this GO :0050793 and regulation of developmental process and biological process this GO :0055008 and cardiac muscle tissue morphogenesis and biological process this GO :0060038 and cardiac muscle cell proliferation and biological process this GO :0060045 and positive regulation of cardiac muscle cell proliferation and biological process this GO :0060253 and negative regulation of glial cell proliferation and biological process this GO :0060271 and cilium morphogenesis and biological process this GO :0060317 and cardiac epithelial to mesenchymal transition and biological process this GO :0060411 and cardiac septum morphogenesis and biological process this GO :0060412 and ventricular septum morphogenesis and biological process this GO :0060528 and secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development and biological process this GO :0060548 and negative regulation of cell death and biological process this GO :0060740 and prostate gland epithelium morphogenesis and biological process this GO :0060768 and regulation of epithelial cell proliferation involved in prostate gland development and biological process this GO :0060842 and arterial endothelial cell differentiation and biological process this GO :0060843 and venous endothelial cell differentiation and biological process this GO :0060948 and cardiac vascular smooth muscle cell development and biological process this GO :0060956 and endocardial cell differentiation and biological process this GO :0060979 and vasculogenesis involved in coronary vascular morphogenesis and biological process this GO :0060982 and coronary artery morphogenesis and biological process this GO :0061314 and Notch signaling involved in heart development and biological process this GO :0061384 and heart trabecula morphogenesis and biological process this GO :0061419 and positive regulation of transcription from RNA polymerase II promoter in response to hypoxia and biological process this GO :0070986 and left/right axis specification and biological process this GO :0071372 and cellular response to follicle-stimulating hormone stimulus and biological process this GO :0071944 and cell periphery and cellular component this GO :0072017 and distal tubule development and biological process this GO :0072044 and collecting duct development and biological process this GO :0072144 and glomerular mesangial cell development and biological process this GO :0072602 and interleukin-4 secretion and biological process this GO :0090051 and negative regulation of cell migration involved in sprouting angiogenesis and biological process this GO :0090090 and negative regulation of canonical Wnt signaling pathway and biological process this GO :0097150 and neuronal stem cell maintenance and biological process this GO :1901201 and regulation of extracellular matrix assembly and biological process this GO :1902263 and apoptotic process involved in embryonic digit morphogenesis and biological process this GO :2000737 and negative regulation of stem cell differentiation and biological process this GO :2000811 and negative regulation of anoikis and biological process this GO :2000974 and negative regulation of pro-B cell differentiation and biological process this GO :2001027 and negative regulation of endothelial cell chemotaxis and biological process, NOTCH1 and IDBG-640538 and ENSBTAG00000022799 and 767866, NOTCH1 and IDBG-92445 and ENSG00000148400 and 4851, Notch1 and IDBG-149571 and ENSMUSG00000026923 and 18128, nuclei, sequence-specific DNA binding, this GO :0000122 and negative regulation of transcription from RNA polymerase II promoter and biological process this GO :0000139 and this GO lgi membrane and cellular component this GO :0001047 and core promoter binding and molecular function this GO :0001190 and RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription and molecular function this GO :0001669 and acrosomal vesicle and cellular component this GO :0001701 and in utero embryonic development and biological process this GO :0001708 and cell fate specification and biological process this GO :0001837 and epithelial to mesenchymal transition and biological process this GO :0001889 and liver development and biological process this GO :0001947 and heart looping and biological process this GO :0002040 and sprouting angiogenesis and biological process this GO :0002052 and positive regulation of neuroblast proliferation and biological process this GO :0002193 and MAML1-RBP-Jkappa- ICN1 complex and cellular component this GO :0002437 and inflammatory response to antigenic stimulus and biological process this GO :0003157 and endocardium development and biological process this GO :0003160 and endocardium morphogenesis and biological process this GO :0003162 and atrioventricular node development and biological process this GO :0003169 and coronary vein morphogenesis and biological process this GO :0003180 and aortic valve morphogenesis and biological process this GO :0003181 and atrioventricular valve morphogenesis and biological process this GO :0003184 and pulmonary valve morphogenesis and biological process this GO :0003192 and mitral valve formation and biological process this GO :0003198 and epithelial to mesenchymal transition involved in endocardial cushion formation and biological process this GO :0003203 and endocardial cushion morphogenesis and biological process this GO :0003207 and cardiac chamber formation and biological process this GO :0003208 and cardiac ventricle morphogenesis and biological process this GO :0003209 and cardiac atrium morphogenesis and biological process this GO :0003213 and cardiac right atrium morphogenesis and biological process this GO :0003214 and cardiac left ventricle morphogenesis and biological process this GO :0003219 and cardiac right ventricle formation and biological process this GO :0003222 and ventricular trabecula myocardium morphogenesis and biological process this GO :0003241 and growth involved in heart morphogenesis and biological process this GO :0003256 and regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation and biological process this GO :0003264 and regulation of cardioblast proliferation and biological process this GO :0003270 and Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation and biological process this GO :0003273 and cell migration involved in endocardial cushion formation and biological process this GO :0003344 and pericardium morphogenesis and biological process this GO :0003682 and chromatin binding and molecular function this GO :0003700 and sequence-specific DNA binding transcription factor activity and molecular function this GO :0004857 and enzyme inhibitor activity and molecular function this GO :0004872 and receptor activity and molecular function this GO :0005509 and calcium ion binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005576 and extracellular region and cellular component this GO :0005634 and nucleus and cellular component this GO :0005654 and nucleoplasm and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005789 and endoplasmic reticulum membrane and cellular component this GO :0005794 and this GO lgi apparatus and cellular component this GO :0005829 and cytosol and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0006355 and regulation of transcription, this GO :0001047 : core promoter binding, this GO :0001047 : core promoter binding and also this GO :0001190 : RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription and also this GO :0003682 : chromatin binding and also this GO :0003700 : sequence-specific DNA binding transcription factor activity and also this GO :0004857 : enzyme inhibitor activity and also this GO :0004872 : receptor activity and also this GO :0005509 : calcium ion binding and also this GO :0005515 : protein binding and also this GO :0019899 : enzyme binding and also this GO :0031490 : chromatin DNA binding and also this GO :0043565 : sequence-specific DNA binding, this GO :0001190 : RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription, this GO :0003682 : chromatin binding, this GO :0003700 : sequence-specific DNA binding transcription factor activity, this GO :0004857 : enzyme inhibitor activity, this GO :0004872 : receptor activity, this GO :0005509 : calcium ion binding, this GO :0005515 : protein binding, this GO :0019899 : enzyme binding, this GO :0031490 : chromatin DNA binding, this GO :0043565 : sequence-specific DNA binding, notch 1 |
| Identity: |
7881 |
| Gene: |
NOTCH1 |
More about : NOTCH1 |
| Long gene name: |
notch 1 |
| Synonyms gene: |
TAN1 |
| Synonyms gene name: |
Notch (Drosophila) homolog 1 (translocation-associated) Notch homolog 1, translocation-associated (Drosophila) |
| Locus: |
9q34, 3 |
| Discovery year: |
1992-02-13 |
| GenBank acession: |
AF308602 |
| Entrez gene record: |
4851 |
| Pubmed identfication: |
1831692 |
| RefSeq identity: |
NM_017617 |
| Classification: |
Ankyrin repeat domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000020935 |