| Long name: |
Activated Notch1 Primary Polyclonal Antibody |
| Also known as: |
Activated Notch1 PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
Neurogenic locus notch homolog protein 1 |
| Specificity: |
This is a highly specific antibody against Neurogenic locus notch homolog protein 1 |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
1754-1780/2555 |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Notch 1 intracellular domain |
| Gene ID number: |
4851 |
| Swiss Prot: |
P46531 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Affects the implementation of differentiation, During cerebellar development, Important for follicular differentiation and possibly cell fate selection within the follicle, Involved in angiogenesis, Involved in determination of left/right symmetry by modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO), Involved in the maturation of both CD4+ and CD8+ cells in the thymus, Jagged2 and Delta1 to regulate cell-fate determination, May be involved in mesoderm development, May enhance HIF1A function by sequestering HIF1AN away from HIF1A, May play an essential role in postimplantation development, Represses neuronal and myogenic differentiation, Required for the THBS4 function in regulating protective astrogenesis from the subventricular zone (SVZ) niche after injury, Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia, negatively regulates endothelial cell proliferation and migration and angiogenic sprouting, probably in some aspect of cell specification and/or differentiation, proliferation and apoptotic programs, somite formation and neurogenesis, Functions as a receptor for membrane-bound ligands Jagged1 |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
AOS5, AOVD1, NOTCH1, Neurogenic locus notch homolog protein 1, Notch 1, TAN1, Translocation-associated notch protein TAN-1, hN1 |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
Activated Notch1 |
| Short name: |
Activated Notch1 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
Activated notch 1 (Antibody to) |
| Alternative technique: |
antibodies |