| Long name: |
FITC Conjugated, NUMBL Polyclonal Antibody |
| Category: |
Conjugated Primary Antibodies |
| Conjugation: |
Anti-FITC Antibody |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
NUMBL |
| Specificity: |
This is a highly specific antibody against NUMBL |
| Modification: |
Unmodified |
| Modification site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
KLH conjugated synthetic peptide derived from human NUMBL |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Crossreactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background: |
CAG3A, CTG3a, Expressed at high levels in developing brain tissue, In mice, LNX1 and Notch 1, NBL, NUMBLIKE or TNRC23, NumbL (NUMB-like protein), NumbL contains one PID (phosphotyrosine interaction domain) and plays an important role in neuronal differentiation, The mammalian NUMB homolog plays a role in the determination of cell fate during development and binds with a variety of proteins, a signaling adapter protein with two protein-protein interaction domains, also known as Numb-R, deletion of the NumbL gene is associated with early embryonic death, including Eps15, is a 609 amino acid cytoplasmic protein that, is thought to play a role in cell fate, like NUMB, namely a phosphotyrosine-binding domain and a proline-rich SH3-binding region (PRR), neuronal cell fate decisions are directed by NUMB, possibly associating with Eps15 and Notch 1, suggesting an essential role for NumbL in early development, In Drosophila |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Excitation Emission: |
494nm/518nm |
| Synonyms: |
NUMB-R CTG3a CAG3A TNRC23 NUMBR NUMBLIKE |
| Properties: |
Bioss Primary Conjugated Antibodies FITC is highly sensitive to pH extremes, FITC has a green emission that's usually collected at 530 nanometers, FITC has a high quantum yield (efficiency of energy transfer from absorption to emission fluorescence) and approximately half of the absorbed photons are emitted as fluorescent light, For fluorescent microscopy applications, This Bioss Primary Conjugated Antibodies Fluorescein isothiocyanate (FITC) antibody is currently after some BD antibodies the most commonly used fluorescent dye for FACS, When excited at 488 nanometers, its photo bleaching effects are not observed due to a very brief interaction at the laser intercept, the 1 FITC is seldom used as it photo bleaches rather quickly though in flow cytometry applications, the FL1 detector of a FACSCalibur or FACScan, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
NUMBL Conjugated |
| Short name: |
FITC Conjugated, NUMBL Antibody |
| Technique: |
Fluorescein, antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label: |
FITC |
| Alternative name: |
fluorecein coupled, numb homolog (Drosophila)-like (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
CAG3A and CTG3a and NBL and NUMB-R and NUMBLIKE and NUMBR and TNRC23, Cytoplasm, NUMBL and IDBG-52025 and ENSG00000105245 and 9253, NUMBL and IDBG-638153 and ENSBTAG00000019461 and 510973, Numbl and IDBG-160322 and ENSMUSG00000063160 and 18223, protein binding, this GO :0005515 and protein binding and molecular function this GO :0005737 and cytoplasm and cellular component this GO :0007399 and nervous system development and biological process this GO :0007405 and neuroblast proliferation and biological process this GO :0007409 and axonogenesis and biological process this GO :0019221 and cytokine-mediated signaling pathway and biological process this GO :0019538 and protein metabolic process and biological process this GO :0021670 and lateral ventricle development and biological process this GO :0021849 and neuroblast division in subventricular zone and biological process this GO :0030900 and forebrain development and biological process this GO :0034332 and adherens junction organization and biological process this GO :0045087 and innate immune response and biological process this GO :0050769 and positive regulation of neurogenesis and biological process this GO :0050775 and positive regulation of dendrite morphogenesis and biological process, this GO :0005515 : protein binding, this GO :0005515 : protein binding, numb homolog (Drosophila)-like |
| Identity: |
8061 |
| Gene: |
NUMBL |
More about : NUMBL |
| Long gene name: |
NUMB like, endocytic adaptor protein |
| Synonyms gene name: |
numb (Drosophila) homolog-like |
| Locus: |
19q13, 2 |
| Discovery year: |
1999-03-12 |
| GenBank acession: |
AF015401 |
| Entrez gene record: |
9253 |
| Pubmed identfication: |
9225980 9303539 |
| RefSeq identity: |
NM_004756 |
| Classification: |
Trinucleotide repeat containing |
| Havana BLAST/BLAT: |
OTTHUMG00000182627 |