| Long name: |
ALEXA FLUOR 350 Conjugated, SLC12A6/KCC3 Polyclonal Antibody |
| Also known as: |
Anti-SLC12A6/KCC3 PAb ALEXA FLUOR 350 |
| Category: |
Conjugated Primary Antibodies |
| Conjugated with: |
350, ALEXA FLUOR® |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
SLC12A6/KCC3 |
| Specificity: |
This is a highly specific antibody against SLC12A6/KCC3 |
| Modification: |
Unmodified |
| Modification Site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human SLC12A6/KCC3 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Cross-reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen: |
Alterations of KCC2 expression in the inferior colliculus of rat brain may be related to seizure susceptibility, Conversely, In neurons, KCC2 expression is correlated with an inhibitory response to GABA, KCC2 expression is limited to neuronal tissues by a restrictive element similar to the neuronal-restrictive silencing factor, KCC3 is not suspected to play a major role in epilepsy, KCC3a and KCC3b, Nitric oxide (NO) donors activate KCCs, The two splice variants of KCC3, The ubiquitously expressed KCC1 contains 12 transmembrane domains with both cytoplasmic N and C terminal domains, are predominantly expressed in brain and kidney, brain, heart and kidney, lung, respectively, while KCC4 is expressed in muscle, while inhibitors of the cGMP pathway prevent NO donor activation, while the absence of KCC2 is necessary for an unusual excitatory response to GABA, The four isoforms of potassium/chloride co-transport channels (KCC) belong to a superfamily of cation-chloride co-transporters involved in cell volume maintenance |
| Purification: |
Purified by Protein A |
| Storage conditions: |
50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission: |
343nm/442nm |
| Properties: |
ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 350 conjugates can be used in multi-color flow cytometry with FACS's equipped with a second red laser or red diode, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
ALEXA FLUOR 350, Alexa Fluor |
| Gene target: |
SLC12A6/KCC3 |
| Short name: |
SLC12A6/KCC3 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Label: |
ALEXA FLUOR 350 |
| Alternative name: |
ALEXA FLUOR 350, SLC12A6/KCC3 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
10914 |
| Gene: |
SLC12A6 |
More about : SLC12A6 |
| Long gene name: |
solute carrier family 12 member 6 |
| Synonyms gene: |
KCC3 ACCPN |
| Synonyms gene name: |
agenesis of corpus callosum and peripheral neuropathy (Andermann syndrome) solute carrier family 12 (potassium/chloride transporter), member 6 |
| Locus: |
15q14 |
| Discovery year: |
1999-05-25 |
| GenBank acession: |
AF108831 |
| Entrez gene record: |
9990 |
| Pubmed identfication: |
10187864 10347194 |
| RefSeq identity: |
NM_005135 |
| Classification: |
Solute carriers |
| Havana BLAST/BLAT: |
OTTHUMG00000129441 |
| Locus Specific Databases: |
Inherited Peripheral Neuropathies Mutation Database LRG_270 |