| Long name: |
Cy5, 5 Conjugated, SIM2 Polyclonal Antibody |
| Category: |
Conjugated Primary Antibodies |
| Conjugation: |
Cy5, 5, 5, Cy5 |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
SIM2 |
| Specificity: |
This is a highly specific antibody against SIM2 |
| Modification: |
Unmodified |
| Modification site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
KLH conjugated synthetic peptide derived from human SIM2 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Crossreactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background: |
AhR, Arnt 1, Both SIM1 and SIM2 inhibit AhR/Arnt dimerization, Several PAS domain family members have been identified including AhR, The Ah receptor nuclear translocator protein 1 (Arnt 1) is required for ligand- dependent nuclear translocation of the Ah receptor and is also necessary for Ah receptor binding to the XRE element, The SIM genes are thought to be involved in the directing and regionalization of tissues during development and the SIM2 gene, The aromatic (aryl) hydrocarbon receptor, and single-minded proteins (SIM1 and SIM2), glutathione S-transferase Ya subunit and DT-diaphorase, is a candidate for the gene responsible for Down syndrome, is a ligand dependent transcription factor that interacts with specific DNA sequences termed xenobiotic responsive elements (XREs) to activate several genes including CYP1A1, thus inhibiting transcriptional activation, which is located on chromosome 21, The Per-Arnt-Sim (PAS) domain was identified as a 270 amino acid motif that mediates associations between various PAS family transcription factors |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Excitation Emission: |
675nm/694nm |
| Synonyms: |
MGC119447 bHLHe15 |
| Properties: |
Cy5 antibodies are excited by the 650-nanometer wave of an argon laser and detected at a 670-nanometer captor, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24° |
| Conjugated: |
These antibodies are excite for emission at 678nm and detected at a 694 , nm wavelengths |
| Gene target: |
SIM2 Conjugated |
| Short name: |
Conjugated, SIM2 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label: |
5, Cy5 |
| Alternative name: |
cyanine 5, 5 coupled, SIM2 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
10883 |
| Gene: |
SIM2 |
More about : SIM2 |
| Long gene name: |
single-minded family bHLH transcription factor 2 |
| Synonyms gene: |
SIM |
| Synonyms gene name: |
single-minded (Drosophila) homolog 2 single-minded homolog 2 (Drosophila) |
| Synonyms name: |
transcription factor SIM2 |
| Locus: |
21q22, 13 |
| Discovery year: |
1995-10-02 |
| Entrez gene record: |
6493 |
| Pubmed identfication: |
7485157 |
| RefSeq identity: |
NM_009586 |
| Classification: |
Basic helix-loop-helix proteins |
| Havana BLAST/BLAT: |
OTTHUMG00000086637 |