| Long name: |
ALEXA FLUOR 488 Conjugated, SIM2 Polyclonal Antibody |
| Also known as: |
Anti-SIM2 PAb ALEXA FLUOR 488 |
| Category: |
Conjugated Primary Antibodies |
| Conjugated with: |
488, ALEXA FLUOR® |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
SIM2 |
| Specificity: |
This is a highly specific antibody against SIM2 |
| Modification: |
Unmodified |
| Modification Site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human SIM2 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Cross-reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen: |
AhR, Arnt 1, Both SIM1 and SIM2 inhibit AhR/Arnt dimerization, Several PAS domain family members have been identified including AhR, The Ah receptor nuclear translocator protein 1 (Arnt 1) is required for ligand- dependent nuclear translocation of the Ah receptor and is also necessary for Ah receptor binding to the XRE element, The SIM genes are thought to be involved in the directing and regionalization of tissues during development and the SIM2 gene, The aromatic (aryl) hydrocarbon receptor, and single-minded proteins (SIM1 and SIM2), glutathione S-transferase Ya subunit and DT-diaphorase, is a candidate for the gene responsible for Down syndrome, is a ligand dependent transcription factor that interacts with specific DNA sequences termed xenobiotic responsive elements (XREs) to activate several genes including CYP1A1, thus inhibiting transcriptional activation, which is located on chromosome 21, The Per-Arnt-Sim (PAS) domain was identified as a 270 amino acid motif that mediates associations between various PAS family transcription factors |
| Purification: |
Purified by Protein A |
| Storage conditions: |
50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission: |
499nm/519nm |
| Synonyms: |
MGC119447 bHLHe15 |
| Properties: |
ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 488 has the same range to that of fluorescein isothiocyanate (FITC), Also Alexa Fluor 488 is pH stable, As a result of this photo stability, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, It is distinguished in the FL1 of a FACS-Calibur or FACScan, has a very high photo stability, it has turned into an antibody for fluorescent microscopy and FACS FLOW cytometry, yet the SIM2 Antibody, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Gene target: |
SIM2 |
| Short name: |
SIM2 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Label: |
ALEXA FLUOR 488 |
| Alternative name: |
ALEXA FLUOR 488, SIM2 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
10883 |
| Gene: |
SIM2 |
More about : SIM2 |
| Long gene name: |
single-minded family bHLH transcription factor 2 |
| Synonyms gene: |
SIM |
| Synonyms gene name: |
single-minded (Drosophila) homolog 2 single-minded homolog 2 (Drosophila) |
| Synonyms name: |
transcription factor SIM2 |
| Locus: |
21q22, 13 |
| Discovery year: |
1995-10-02 |
| Entrez gene record: |
6493 |
| Pubmed identfication: |
7485157 |
| RefSeq identity: |
NM_009586 |
| Classification: |
Basic helix-loop-helix proteins |
| Havana BLAST/BLAT: |
OTTHUMG00000086637 |